Found 25 matching trials
Impact of Rifabutin on the Pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor
PHASE4This is a prospective, single-center, fixed-sequence, nonrandomized, open-l...
Location
University of Southern California
Proof-of-concept Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of SION-719 When Added to Trikafta
PHASE2The purpose of this study is to evaluate the safety, tolerability, pharmaco...
Status
Active Not Recruiting
Location
National Jewish Health
Pharmacokinetics of CFTR Modulators in Pregnant Individuals and in Postpartum Breastfeeding Mothers
N/AThis study aims to evaluate the pharmacokinetic changes during pregnancy, p...
Location
University of Minnesota
Real World Clinical Outcomes With Novel Modulator Therapy Combinations in People With CF (RECOVER)
PHASE4RECOVER is a prospective, multicenter observational study designed to measu...
Status
Active Not Recruiting
Location
Children's Health Ireland at Crumlin
Impact of Elexacaftor-Tezacaftor-Ivacaftor Treatment on Metabolic, Epigenetic and Fecal Microbiota Profiles in People With Cystic Fibrosis.
N/ACystic Fibrosis (CF) is a genetic disease that affects multiple organs and ...
Location
Centro per la Fibrosi Cistica, Azienda Universitaria Ospedaliera Consorziale Policlinico
Trikafta in Cystic Fibrosis Patients
PHASE2This clinical study will enroll 42 participants without the F508del mutatio...
Location
University of Alabama Cystic Fibrosis Research Center
BEGIN Novel ImagiNG Biomarkers
PHASE4To determine the treatment effect of triple-combination therapy in 6-8 year...
Location
University of Kansas Medical Center
Trikafta for Patients With Non-cystic Fibrosis Bronchiectasis
PHASE4Study participants with non-cystic fibrosis bronchiectasis will be given Tr...
HERO-2: Home-Reported Outcomes With CFTR Modulator Therapy
N/AThis is an observational cohort study, using data from Folia Health and the...
Location
Indiana University School of Medicine
Rethinking Early Airway Clearence Therapies
NAThe REACT trial consists of two parallel, randomized studies; the Hypertoni...
Location
The Children's Hospital Alabama, University of Alabama at Birmingham