Found 24 matching trials
A Pharmacokinetics Study of the Effects of GSK2118436 on Warfarin, the Effects of Ketoconazole and Gemfibrozil on GSK2118436, and the Effects of Repeat Doses of GSK2118436 in Subjects With BRAF Mutant Solid Tumors PHASE1 GSK2118436 is an orally administered, potent and selective small molecule B...
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GSK Investigational Site
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A Clinical Trial of Patients With Melanoma PHASE1 This study is being done to find out if the combination of dabrafenib, tram...
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University of Texas Southwestern Medical Center
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Dabrafenib and Trametinib in People With BRAF V600E Mutation Positive Lesions in Erdheim Chester Disease PHASE2 Erdheim-Chester Diseases (ECD) is a very rare non-Langerhans cell histiocyt...
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National Institutes of Health Clinical Center, 9000 Rockville Pike
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MCS110 With BRAF/MEK Inhibition in Patients With Melanoma PHASE1 This research study is studying a combination of targeted therapies as a po...
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Dana Farber Cancer Institute
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Neoadjuvant and Adjuvant Targeted Treatment in NSCLC With BRAF V600 or MET Exon 14 Mutations PHASE2 This is a Phase II, two parallel group study assessing the efficacy and saf...
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Cancer Center of Sun-Yat Sen University
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Combining Talimogene Laherparepvec With BRAF and MEK Inhibitors in BRAF Mutated Advanced Melanoma PHASE1 The purpose of the study is to determine safety and tolerability of the com...
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West Cancer Center
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A Pharmacokinetics (PK) Study of the Effects Rabeprazole and Rifampin on Dabrafenib in Subjects With BRAF V600 Mutation Positive Tumors PHASE1 The study is being conducted to evaluate the effect of rifampin (a strong C...
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GSK Investigational Site
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Neoadjuvant Dabrafenib, Trametinib and/or Pembrolizumab in BRAF Mutant Resectable Stage III Melanoma PHASE2 This study aims to determine which of 3 drug combinations best reduces the ...
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Active Not Recruiting
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Westmead Hospital
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Cetuximab in Combination With Dabrafenib and Tislelizumab in BRAF Mutated Treatment of Advanced Colorectal Cancer NA To explore the efficacy and safety of Cetuximab in combination with dabrafe...
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Zhejiang Cancer Institute & Hospital
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Clinical Trial in RAI-Refractory Thyroid Carcinoma Evaluating BRAF & MEK Blockade for Re-differentiation Therapy PHASE2 Progressive and metastatic thyroid cancer patients, who no longer respond t...
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National University Hospital
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