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Study of the Anti-PD-1 Antibody Nivolumab in Combination With Dabrafenib and/or Trametinib PHASE1 This study evaluates nivolumab in combination drug treatments involving 1) ...
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Multiple Locations
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Nilotinib Plus Dabrafenib/Trametinib or Encorafenib/Binimetinib in Metastatic Melanoma PHASE1 This is a phase 1 dose-escalation study of nilotinib in combination with fi...
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University of Iowa
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Precision Medicine Trial Based on Molecular Matching Therapy for Patients With Standard Treatment Exhaustion PHASE2 The main purpose of this study is to explore the feasibility of selecting t...
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Tianjin Medical Unversity Second Hospital
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Concurrent Dabrafenib + Trametinib With Sterotactic Radiation in BRAF Mutation-Positive Malignant Melanoma and Brain Metastases PHASE2 Dabrafenib and trametinib are drugs that are usually given for the treatmen...
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QEII Health Sciences Centre
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A Prospective, Multi-Centre Trial of TKI Redifferentiation Therapy in Patients With RAIR Thyroid Cancer (I-FIRST Study) PHASE2 This prospective, multi-centre, open label, non-randomised phase II trial a...
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Royal North Shore Hospital
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Continuous vs Intermittent Dabrafenib Plus Trametinib in BRAFV600 Mutant Stage 3 Unresectable or Metastatic Melanoma PHASE2 This feasibility study aims to determine if intermittent dosing is delivera...
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Addenbrooke's Hospital
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Re-differentiation of Radioiodine-Refractory BRAF V600E-mutant Papillary Thyroid Carcinoma With GSK2118436 NA Radioactive iodine therapy is often part of the standard treatment for Papi...
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Massachusetts General Hospital
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A Phase II Study of Sintilimab Combined With Ipilimumab N01, Cetuximab and Dabrafenib in Patients With Microsatellite-Stable, BRAF V600E-Mutated Metastatic Colorectal Cancer PHASE2 Colorectal cancer (CRC) is the second leading cause of cancer-related death...
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Peking union medical college hospital
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Neoadjuvant Dabrafenib + Trametinib for AJCC Stage IIIB-C BRAF V600 Mutation Positive Melanoma PHASE2 This is an open label, single centre, phase II study of neoadjuvant drug tr...
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Melanoma Institute Australia
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Study of Selective BRAF Kinase Inhibitor Dabrafenib Monotherapy Twice Daily and in Combination With Dabrafenib Twice Daily and Trametinib Once Daily in Combination Therapy in Subjects With BRAF V600E Mutation Positive Metastatic (Stage IV) Non-small Cell Lung Cancer. PHASE2 This was a Phase II, multicenter, non-randomized, open-label study to asses...
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Novartis Investigative Site
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