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Study of LDE225 (Sonidegib) in Combination With Docetaxel in Triple Negative (TN) Advanced Breast Cancer (ABC) Patients PHASE1 This is a single-arm, open-label, phase Ib study. In this trial, patients w...
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Complejo Hospitalario Universitario A Coruña
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Oral Hedgehog Inhibitors in the Treatment of Basal Cell Carcinoma in the Netherlands: a Prospective Registration Study N/A Background: Oral hedgehog inhibitors vismodegib and sonidegib have been use...
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Combination of the Hedgehog Inhibitor, LDE225, With Etoposide and Cisplatin in the First-Line Treatment of Patients With Extensive Stage Small Cell Lung Cancer (ES-SCLC) PHASE1 The purpose of this study is to test the safety of study drug LDE225 at dif...
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Memoral Sloan Kettering Cancer Center
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LDE225 in Patients With Advanced or Metastatic Hepatocellular Carcinoma and Child-Pugh A/B7 Cirrhosis PHASE1 The purpose of this study is to test the safety and determine the maximum s...
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UCSD Moores Cancer Center
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Phase I Study to Evaluate the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients PHASE1 This is a multi center, open-label study to evaluate the drug-drug interact...
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City of Hope National Medical Center Oncology
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Sonidegib in Adult Patients With Locally Advanced Basal Cell Carcinoma (laBCC) in China PHASE4 This is a Phase IV, single arm, multicenter study designed to evaluate the ...
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Peking University First Hospital
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Pilot Study of Sonidegib and Buparlisib in Treating Patients With Advanced or Metastatic Basal Cell Carcinoma PHASE2 This pilot trial studies how well sonidegib and buparlisib work in treating...
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Stanford University School of Medicine
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Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors NA This is a prospective single-center, open label, pilot study to investigate...
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Stanford University, School of Medicine
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A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma PHASE2 In this study, patients with BCC will be given neoadjuvant treatment with a...
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Melanoma Institute Australia
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Efficacy, Safety and Pharmacokinetics of Oral LDE225 in Treatment of Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS) PHASE2 This was a phase II, double-blind, randomized, proof-of-concept, dose-rangi...
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Novartis Investigative Site
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