Found 39 matching trials
Peginterferon Lambda and Lonafarnib Boosted With Ritonavir 48-Week Combination Therapy for Delta Hepatitis PHASE2 Background:
Chronic hepatitis D is a serious liver disease caused by a vir...
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National Institutes of Health Clinical Center
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PH I Addition of Farnesyl Transferase Inhibitor to Temozolomide for Pts w Gr 3 & 4 Malignant Gliomas PHASE1 Objectives:
To determine maximum tolerated dose of farnesyl transferase in...
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Duke University Health System
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Study to Determine Optimal Dose and Evaluate Safety, Tolerability, and Pharmacokinetics of Progerinin in Patients With Hutchinson-Gilford Progeria Syndrome (HGPS) PHASE2 Researchers will compare treatment with progerinin plus lonafarnib vs lonaf...
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Active Not Recruiting
Location
Boston Children's Hospital
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SCH 66336 Before Surgery in Treating Patients With Colorectal Cancer That Has Metastasized to the Liver PHASE1 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cell...
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Multiple Locations
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Treatment of Chronic Delta Hepatitis With Lonafarnib, Ritonavir and Lambda Interferon PHASE2 Background:
Infection with hepatitis D virus leads to a chronic liver dise...
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National Institutes of Health Clinical Center
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4-HPR and FTI in Head and Neck Squamous Cell Carcinoma (HNSCC) PHASE1 The primary objective of this study is to estimate the modulation of interm...
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UT MD Anderson Cancer Center
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Study of Lonafarnib Versus Placebo in Subjects With Either Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML) (Study P02978AM3)(TERMINATED) PHASE3 The purpose of this study is to assess the benefit of lonafarnib (versus pl...
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Multiple Locations
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Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria PHASE2 Hutchinson-Gilford Progeria Syndrome (Progeria) is a rare autosomal disease...
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Children's Hospital Boston
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Comparison of Paclitaxel/Carboplatin and Lonafarnib to Paclitaxel/Carboplatin for First-line Treatment of Ovarian Cancer PHASE2 The purpose of this study is to compare the effects of Paclitaxel/Carboplat...
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Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Klinik für Frauenheilkunde
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A Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria PHASE2 This is an open label single arm feasibility trial. A combination of two or...
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Children's Hospital Boston
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