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Trial Search

Current Search Criteria:

Intervention: bempegaldesleukin

Found 22 matching trials

A Study to Compare Bempegaldesleukin (BEMPEG: NKTR-214) Combined With Nivolumab and Tyrosine Kinase Inhibitor (TKI) to Nivolumab and TKI Alone in Participants With Previously Untreated Kidney Cancer That is Advanced or Has Spread

PHASE1

The purpose of this study is in Part 1, to determine the safety of nivoluma...

Status

Completed

Location

Local Institution - 0005

Start Date

2020-09-11

Trial ID

NCT04540705

Treatments Being Tested

Nivolumab Axitinib Cabozantinib

A Study of NKTR-214 Combined With Nivolumab vs Nivolumab Alone in Participants With Previously Untreated Inoperable or Metastatic Melanoma

PHASE3

The purpose of the study is to test the effectiveness (how well the drug wo...

Status

Completed

Location

Local Institution - 0187

Start Date

2018-09-21

Trial ID

NCT03635983

Treatments Being Tested

NKTR-214 Nivolumab

A Study of Nivolumab Plus Bempegaldesleukin (Bempeg/NKTR-214) vs Nivolumab Alone vs Standard of Care in Participants With Bladder Cancer That May Have Invaded The Muscle Wall of the Bladder and Who Cannot Get Cisplatin, A Type of Medicine Given To Treat Bladder Cancer

PHASE3

The purpose of the study is to see if treatment with nivolumab plus bempega...

Status

Completed

Location

Local Institution - 0080

Start Date

2020-02-05

Trial ID

NCT04209114

Treatments Being Tested

Nivolumab Radical cystectomy (RC)Bempegaldesleukin

A Study to Evaluate Safety and Efficacy of Multiple Dosing With VB10.NEO and Bempegaldesleukin (NKTR-214) Immunotherapy in Patients With Locally Advanced or Metastatic Cancer

PHASE1

This open labelled first in human dose phase 1/2a study is designed to eval...

Status

Completed

Location

Charité Research Organisation, Campus Benjamin Franklin

Start Date

2018-04-04

Trial ID

NCT03548467

Treatments Being Tested

VB10.NEO Bempegaldesleukin

Platform Study for Prostate Researching Translational Endpoints Correlated to Response to Inform Use of Novel Combinations

PHASE1

This study is designed to evaluate multiple clinical hypotheses and mechani...

Status

Completed

Location

Angeles Clinic

Start Date

2019-06-21

Trial ID

NCT03835533

Treatments Being Tested

NKTR-214 (Cohort A)Nivolumab (Cohort A, B and C)Stereotactic body radiation therapy (SBRT) (Cohort B)CDX-301 (Cohort B and C)Poly-ICLC (Cohort B)INO-5151 (Cohort C)Cellectra 2000

A Single-Arm Study of Bempegaldesleukin (NKTR-214) Plus Nivolumab in Cisplatin Ineligible Patients Who Have Locally Advanced or Metastatic Urothelial Cancer

PHASE2

The main purpose of this study is to evaluate the anti-tumor activity of be...

Status

Completed

Location

San Francisco VA Medical Center - NAVREF - PPDS

Start Date

2019-04-29

Trial ID

NCT03785925

Treatments Being Tested

Bempegaldesleukin Nivolumab

A Dose Escalation and Cohort Expansion Study of NKTR-214 in Combination With Nivolumab and Other Anti-Cancer Therapies in Patients With Select Advanced Solid Tumors

PHASE1

In this four-part study, NKTR-214 was administered in combination with nivo...

Status

Completed

Location

UCSD, Moores Cancer Center

Start Date

2016-12-19

Trial ID

NCT02983045

Treatments Being Tested

Dose Escalation Doublet: Combination of NKTR-214 + nivolumab Dose Expansion Doublet: Combination of NKTR-214 + nivolumab Schedule Finding Triplet: Combination of NKTR-214+ nivolumab+ ipilimumab Dose Expansion Triplet: Combination of NKTR-214+ nivolumab+ ipilimumab

A Prospective, Single-arm, Multicenter Exploratory Clinical Study of Anlotinib Combined With Bempegaldesleukin and Conventional Chemoradiotherapy for the Treatment of Unresectable Locally Advanced or Metastatic Soft Tissue Sarcoma.

PHASE2

This study employs a multicenter, single-arm trial design. Participants wil...

Status

Not Yet Recruiting

Location

Jiangsu Province Hospital

Start Date

2025-10-01

Trial ID

NCT07156643

Treatments Being Tested

Anlotinib and bempegaldesleukin

A Placebo Controlled Trial of Bempegaldesleukin (BEMPEG; NKTR-214) With Standard of Care in Patients With Mild COVID-19

PHASE1

The main purpose of this phase-1b, multicenter, randomized double-blind, pl...

Status

Completed

Location

A G A Clinical Trials - HyperCore - PPDS

Start Date

2020-11-13

Trial ID

NCT04646044

Treatments Being Tested

Bempegaldesleukin Standard of Care Placebo

A Study of Bempegaldesleukin (NKTR-214: BEMPEG) in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy (Either Sunitinib or Cabozantinib Monotherapy) for Advanced Metastatic Renal Cell Carcinoma (RCC)

PHASE3

The main purpose of this study is to compare the objective response rate (O...

Status

Terminated

Location

Alaska Urological

Start Date

2018-12-18

Trial ID

NCT03729245

Treatments Being Tested

bempegaldesleukin sunitinib nivolumab cabozantinib

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