Found 11 matching trials
Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX) PHASE1 The purpose of this study is to evaluate the tolerability and safety of Xev...
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Mount Sinai Comprehensive Cancer Center
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Study to Assess Xevinapant in Preoperative Subjects With Recurrent High-Grade Glioma (rHGG) PHASE1 Researchers will investigate the ability of Xevinapant to cross the blood-b...
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Multiple Locations
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Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION) PHASE3 The purpose of this study is to demonstrate the superior efficacy of Xevina...
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University of Alabama at Birmingham - Dept of Radiation Oncology
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PK Study of Xevinapant (Debio 1143) in Healthy East Asian Participants PHASE1 The purpose of this study was to evaluate the pharmacokinetics (PK) of Xevi...
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Labcorp Clinical Research Unit Limited
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Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer PHASE2 This phase II trial compares the effect of usual radiation therapy with cis...
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Multiple Locations
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A Study to Evaluate the Absorption, Metabolism, and Excretion and Absolute Bioavailability of Xevinapant in Healthy Male Participants PHASE1 The purpose of the study is to determine absorption, metabolism, and excret...
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Labcorp Clinical Research Unit
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A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX) PHASE3 The primary objective of the study was to demonstrate superior efficacy of ...
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The University of Alabama at Birmingham - Hazelrig-Salter Radiation Oncology Center (HSROC)
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A Study of Xevinapant With Cisplatin and Radiation Therapy After Surgery in People With Head and Neck Cancer PHASE2 The purpose of this study is to test whether treatment with Xevinapant adde...
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Memorial Sloan Kettering Basking Ridge
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Study Comparing RT With Cetuximab + Xevinapant to RT With Cetuximab-placebo in Patients With Head and Neck Cancer PHASE3 Xevinapant is an antagonist of inhibitor of apoptosis proteins (IAPs) that ...
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Hôpital Nord Franche Compté
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Radiotherapy Plus Xevinapant in Older Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma PHASE2 This is a multicenter, randomized, placebo-controlled, triple blind, phase ...
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Onze Lieve Vrouw Ziekenhuis
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