Found 12 matching trials
Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age PHASE3 The purpose of this study is to evaluate the pharmacokinetics, safety, tole...
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Active Not Recruiting
Location
Children's Hospital of Orange County
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Effect of Vanzacaftor/Tezacaftor/Deutivacaftor (VNZ/TEZ/D-IVA) on the PK of Rosuvastatin in Healthy Participants PHASE1 The purpose of this study is to evaluate the effect of multiple doses of va...
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Altasciences - Kansas City
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A Study To Evaluate the Relative Bioavailability, Food Effect, and Dose Proportionality of a Granule Formulation of Vanzacaftor/Tezacaftor/Deutivacaftor(VNZ/TEZ/D-IVA) PHASE1 The purpose of this study is to evaluate the relative bioavailability, food...
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Pharmacokinetics and Safety Assessment of VX-121/Tezacaftor/Deutivacaftor in Participants With Moderate Hepatic Impairment PHASE1 The purpose of this study is to evaluate the pharmacokinetics (PK) and safe...
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Clinical Pharmacology of Miami, LLC
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A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy PHASE3 The purpose of this study is to evaluate the long-term safety, tolerability...
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Active Not Recruiting
Location
University of Alabama at Birmingham
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A Study to Evaluate the Relative Bioavailability of a Fixed-dose Combination Tablet of VX-121/Tezacaftor/Deutivacaftor PHASE1 The purpose of this study is to evaluate the relative bioavailability of a ...
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ICON Salt Lake City
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Evaluation of Long-Term Safety and Efficacy of Vanzacaftor/Tezacaftor/Deutivacaftor in Cystic Fibrosis Participants 1 Year of Age and Older PHASE3 The purpose of this study is to evaluate the long-term safety, tolerability...
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Enrolling By Invitation
Location
Children's Hospital of Orange County
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A Study of Vanzacaftor/Tezacaftor/Deutivacaftor (VNZ/TEZ/D-IVA) in Healthy Adult Panelists PHASE1 The purpose of this study is to evaluate the flavor (basic tastes, aroma, t...
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Study of VX-121 in Healthy Subjects and in Subjects With Cystic Fibrosis PHASE1 The purpose of this study is to evaluate safety and tolerability of VX-121 ...
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Academic Medical Center
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A Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Who Are Homozygous for F508del, Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation, or Have At Least 1 Other Triple Combination Responsive (TCR) CFTR Mutation and No F508del Mutation PHASE3 The purpose of this study is to evaluate the efficacy and safety of VX-121/...
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University of Alabama at Birmingham
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