Found 10 matching trials
Lorlatinib Combinations in Lung Cancer PHASE1 This research study is evaluating Lorlatinib in combination with Crizotinib...
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Massachusetts General Hospital Cancer Center
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Pharmacokinetics of TNO155 in Participants With Mild, Moderate, or Severe Hepatic Impairment Compared to Matched Healthy Participants PHASE1 The purpose of this study is to evaluate the effect of various degrees of h...
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Multiple Locations
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Adagrasib in Combination With TNO155 in Patients With Cancer (KRYSTAL 2) PHASE1 This study will evaluate the safety, tolerability, drug levels, molecular e...
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Local Institution - 002-805
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Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies PHASE1 This study was a Phase Ib, multi-center, open-label study of TNO155 in comb...
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Massachusetts General Hospital
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Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101) PHASE1 To evaluate the safety and tolerability of sotorasib administered in invest...
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Active Not Recruiting
Location
Arizona Oncology Associates Professional Corporation
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Pharmacokinetics Study of TNO155 in Participants With Mild, Moderate, or Severe Renal Impairment Compared to Matched Healthy Participants PHASE1 The purpose of this Phase 1 study is to evaluate the effect of various degr...
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Multiple Locations
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Dose Finding Study of TNO155 in Adult Patients With Advanced Solid Tumors PHASE1 The purpose of this first in human (FIH) trial was to characterize the safe...
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H Lee Moffitt Cancer Center and Research Institute
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Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation PHASE1 This is a phase Ib/II open label study. The escalation part will characteri...
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Active Not Recruiting
Location
Emory University School of Medicine-Winship Cancer Institute
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A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal Cancer PHASE1 A phase Ib, open-label platform study of select drug combinations chosen in...
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University of California LA Santa Monica Location
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Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments PHASE1 The purpose of this study is to allow continued access to opnurasib (JDQ443...
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Novartis Investigative Site
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