Found 58 matching trials
A Study to Evaluate Safety and Pharmacokinetics of VX-659 in Healthy Subjects and in Adults With Cystic Fibrosis PHASE1 Evaluate the safety and tolerability of VX-659 in healthy subjects...
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Multiple Locations
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A Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis (CF) Particpants 6 Years and Older and F/MF Genotypes PHASE3 The study evaluates the long-term safety and efficacy of elexacaftor (ELX)/...
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Telethon Kids Institute
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A Phase 2 Study to Evaluate Effects of VX-661/Ivacaftor on Lung and Extrapulmonary Systems in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation PHASE2 To evaluate the clinical mechanisms of action in lung and extrapulmonary sy...
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Multiple Locations
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A Study Evaluating the Safety and Efficacy of VX-659 Combination Therapy in Subjects With Cystic Fibrosis PHASE2 This is a Phase 2, randomized, double-blind, placebo- and tezacaftor/ivacaf...
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Yale New Haven Hospital
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Impact of Rifabutin on the Pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor PHASE4 This is a prospective, single-center, fixed-sequence, nonrandomized, open-l...
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University of Southern California
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Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age PHASE3 The purpose of this study is to evaluate the pharmacokinetics, safety, tole...
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Active Not Recruiting
Location
Children's Hospital of Orange County
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A Study to Assess the Effect of ELX/TEZ/IVA on Glucose Tolerance in Participants With Cystic Fibrosis (CF) PHASE3 This study was evaluate the effect of elexacaftor (ELX)/tezacaftor (TEZ)/iv...
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Royal Adelaide Hospital
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Effect of Vanzacaftor/Tezacaftor/Deutivacaftor (VNZ/TEZ/D-IVA) on the PK of Rosuvastatin in Healthy Participants PHASE1 The purpose of this study is to evaluate the effect of multiple doses of va...
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Altasciences - Kansas City
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Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Participants 12 Months of Age and Older PHASE3 The purpose of the study is to evaluate the long-term safety, tolerability,...
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Active Not Recruiting
Location
The Kids Research Institute Australia
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A Study Evaluating the Safety of VX-152 Combination Therapy in Adults With Cystic Fibrosis PHASE2 This is a Phase 2, randomized, double blind, placebo and active-controlled,...
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Multiple Locations
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