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Trial Search

Current Search Criteria:

Intervention: TCR-T therapy

Found 414 matching trials

A Pilot Study of Vaccination With Epitope-Enhanced TARP Peptide and TARP Peptide-Pulsed Dendritic Cells in the Treatment of Stage D0 Prostate Cancer

PHASE1

Background: * PSA (prostate specific antigen) is a protein found on normal...

Status

Completed

Location

National Institutes of Health Clinical Center, 9000 Rockville Pike

Start Date

2009-05-11

Trial ID

NCT00972309

Treatments Being Tested

T-cell receptor alternate reading frame protein (TARP) peptide vaccine T-cell receptor alternate reading frame protein (TARP) dendritic cell vaccine

T Cell Receptor Immunotherapy Targeting MAGE-A3 for Patients With Metastatic Cancer Who Are HLA-DP0401 Positive

PHASE1

Background: The National Cancer Institute (NCI) Surgery Branch has develop...

Status

Completed

Location

National Institutes of Health Clinical Center, 9000 Rockville Pike

Start Date

2014-02-07

Trial ID

NCT02111850

Treatments Being Tested

Anti-MAGE-A3-DP4 T Cell Receptor (TCR) Peripheral Blood Lymphocytes (PBL)Cyclophosphamide Fludarabine Aldesleukin

Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Solid Tumor Cancers With KRAS G12V Mutations

PHASE1

This phase I trial studies the side effects and best dose of autologous CD8...

Status

Recruiting

Location

Fred Hutch/University of Washington Cancer Consortium

Start Date

2023-12-15

Trial ID

NCT06043713

Treatments Being Tested

Bendamustine Biopsy Biospecimen Collection Computed Tomography Cyclophosphamide Echocardiography Fludarabine Leukapheresis Magnetic Resonance Imaging Multigated Acquisition Scan Positron Emission Tomography T-cell Receptor-engineered T-cells

Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR After a Myeloablative Conditioning Regimen to Treat Patients With Advanced Cancer

PHASE1

This phase I clinical trial evaluates the safety and feasibility of adminis...

Status

Terminated

Location

UCLA / Jonsson Comprehensive Cancer Center

Start Date

2017-07-26

Trial ID

NCT03240861

Treatments Being Tested

18F-FHBG Aldesleukin Busulfan Cellular Therapy Computed Tomography Filgrastim Fludarabine Leukapheresis Plerixafor Positron Emission Tomography

Anti-PD-1 Antibody Plus Regorafenib in Refractory Microsatellite Stable Metastatic Colorectal Cancer

N/A

Managements for refractory proficient mismatch repair (pMMR) or microsatell...

Status

Completed

Location

Hunan Cancer hospital

Start Date

2019-07-01

Trial ID

NCT05942768

Treatments Being Tested

regorafenib plus anti-PD-1 antibodies

Ipilimumab in Treating Patients With Relapsed or Refractory High-Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia

PHASE1

This phase I trial studies the side effects and best dose of ipilimumab and...

Status

Completed

Location

Yale University

Start Date

2012-12-14

Trial ID

NCT01757639

Treatments Being Tested

Ipilimumab Laboratory Biomarker Analysis

Genetically Engineered Cells (MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells) and Atezolizumab for the Treatment of Metastatic Triple Negative Breast Cancer, Urothelial Cancer, or Non-small Cell Lung Cancer

PHASE1

This phase I/II trial investigates the side effects of genetically engineer...

Status

Terminated

Location

Fred Hutch/University of Washington Cancer Consortium

Start Date

2021-07-19

Trial ID

NCT04639245

Treatments Being Tested

Atezolizumab Cyclophosphamide Fludarabine MAGE-A1-specific T Cell Receptor-transduced Autologous T-cells PD1 Inhibitor

A Long Term Follow-up Study of TScan TCR-T Products

N/A

The purpose of this Long-Term Follow-Up (LTFU) study is to monitor particip...

Status

Recruiting

Location

City of Hope

Start Date

2025-09-09

Trial ID

NCT06976736

Treatments Being Tested

Observational

Nivolumab With or Without Ipilimumab in Treating Patients With Persistent or Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

PHASE2

This randomized phase II trial studies how well nivolumab works with or wit...

Status

Completed

Location

Sutter Auburn Faith Hospital

Start Date

2015-08-10

Trial ID

NCT02498600

Treatments Being Tested

Ipilimumab Nivolumab

TAA6 Cell Injection In The Treatment of Patients With Relapsed / Refractory Acute Myeloid Leukemia

This is a clinical study of TAA6 cell injection in the treatment of patient...

Status

Unknown

Location

Anhui Provincial Hospital

Start Date

2019-12-09

Trial ID

NCT04692948

Treatments Being Tested

Chimeric antigen receptor T cells (car-t)

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