Found 19 matching trials
Trastuzumab Deruxtecan Versus Standard Neoadjuvant Treatment for HER2-positive Breast Cancer
PHASE2The goal of this clinical trial is to compare trastuzumab deruxtecan (T-DXd...
Location
Skåne University Hospital
Personalized Detection of ctDNA for Patients With HER2-Positive Metastatic Breast Cancer Patients Who Achieved Durable Response to Anti-HER2 Treatment
N/AAnti-HER2 therapy, such as trastuzumab and pertuzumab, has significantly im...
Status
Active Not Recruiting
NeoAdjuvant Therapy With Trastuzumab-deruxtecan Versus Chemotherapy+Trastuzumab+Pertuzumab in HER2+ Early Breast Cancer
PHASE2ADAPT-HER2-IV will address question of optimal neoadjuvant therapy in patie...
Location
Klinikum Mittelbaden, Brustzentrum
Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer
PHASE3This study will look at the efficacy and safety of trastuzumab deruxtecan (...
Status
Active Not Recruiting
PHESGO Maintenance After T-DXd Short Induction for HER2+ Unresectable Locally Recurrent or Metastatic Breast Cancer
PHASE2DEMETHER is a phase II trial exploring the maintenance of trastuzumab and p...
Status
Active Not Recruiting
Location
Dana-Farber Cancer Institute
T-DXd Versus THP for Medium-risk HER2-positive Early Breast Cancer
PHASE2This study (EXTEND trial) is a multicentre, interventional, prospective, ra...
Location
Fudan University Shanghai Cancer Center
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
PHASE2The purpose of this study is to further advance the ability to practice per...
Location
University of Alabama at Birmingham
T-DXd Based Therapy Followed by Endocrine Therapy Plus Dual HER2 Blockade in First-line HER2+/ HR+ Metastatic Breast Cancer and Retreatment With T-DXd
PHASE3This study will evaluate a structured sequential treatment strategy startin...
Location
Multiple Locations
HERizon-Breast: A ctDNA-Guided Adaptive Study of Sequential Anti-HER2 Therapies and CNS Prophylaxis to Induce Long-Term Remission
PHASE2Thie purpose of this study is to find out whether a personalized treatment ...
Location
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer
PHASE1DESTINY-Breast07 will investigate the safety, tolerability, and anti-tumour...
Status
Active Not Recruiting