Found 28 matching trials
Tolcapone in Obsessive Compulsive Disorder
PHASE2The proposed study will consist of a 5-week double-blind cross-over study t...
Location
University of Chicago
Evaluate the Effects of Tolcapone on Cognitive and Behavioral Dysfunction in Patients With BI and NCD
PHASE2The experimental design is an open-label two-week trial of tolcapone to eva...
Location
Sheppard Pratt Health System
A Study of Neural Circuit Responses to Catechol-O-methyl Transferase (COMT) Inhibitors
NAIn this study, we seek to understand the effects of tolcapone, an FDA-appro...
Location
University of California, Berkeley
Tolcapone Treatment of Pathological Gambling
PHASE2The goal of the proposed study is to evaluate the efficacy and safety of to...
Location
Ambulatory Research Center
Microbiome Derived Metabolism and Pharmacokinetics
PHASE1The investigators will perform single-dose pharmacokinetic (PK) studies in ...
Location
Robert Wood Johnson University Hospital Somerset
Role of the Catechol-O-methyltransferase (COMT) in the Physiological Regulation of Vigilance
PHASE1In this study, pharmacologic effects of COMT inhibition during sleep depriv...
Location
University of Zurich, Institute of Pharmacology and Toxicology
Neural Substrates in Nicotine Withdrawal
PHASE2This study will test the hypothesis that a medication called tolcapone (Bra...
Location
University of Pennsylvania
Remediation of Impaired Self-Regulation in Patients With Mild TBI
EARLY_PHASE1The ability to regulate impulses enables us to plan for the future, to main...
Location
VA Northern California Health Care System, Mather, CA
Pilot Study of Tolcapone in Smokers
PHASE2The goals of this within-subject pilot study are: (1) assess the feasibilit...
Location
University of Pennsylvania
Study of SOM0226 in Familial Amyloid Polyneuropathy
PHASE1Clinical proof of concept study to evaluate SOM0226 efficacy in TTR Amyloid...
Location
Hospital Vall d'Hebron