Found 15 matching trials
Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone in Volunteers With Impaired Hepatic Function PHASE1 This is a multicenter, non-randomized, single-dose, parallel-group study. E...
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Progenics Pharmaceuticals, Inc.
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Effects of MNTX on CYP450 2D6 in Metabolizers of Dextromethorphan PHASE1 This study is a single-center, randomized, open-label, active and placebo-c...
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Progenics Pharmaceuticals
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Effects of 500 mg Immediate Release and Extended Release Methylnaltrexone on Loperamide-induced Delay of the Oro-cecal and Whole-gut Transit Time in Healthy Subjects PHASE1 The purpose of this study is to describe the effects of methylnaltrexone in...
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Department of Clinical Pharmacology, Ernst-Moritz-Arndt-University Greifswald
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Pharmacokinetics and Bioavailability of Single Subcutaneous Doses of Methylnaltrexone Versus Intravenous Dose PHASE1 This is an open-label, Phase I study. Study treatments will entail a four-w...
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Progenics Pharmaceuticals, Inc.
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A a Single Dose Efficacy Study in Inducing Laxation in Advance Illness Patients PHASE3 To test the effectiveness of MNTX in advanced illness subjects....
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Progenics Pharmaceuticals, Inc.
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Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone (MNTX) in Subjects With Impaired Renal Function PHASE1 This study is evaluating the Pharmacokinetics of MNTX in healthy control su...
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Progenics Pharmaceuticals, Inc.
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Methylnatrexone In Resectable Head and Neck Squamous Cell Carcinoma (MINK). A "Window of Opportunity" Pilot Study. PHASE4 To learn if OCSCC patients can be safely given methylnaltrexone for 2 weeks...
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MD Anderson Cancer Center
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Open-Label Treatment Extension of Protocol MNTX 302 PHASE3 This is a 3 month open-label extension study that allows patients who compl...
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Progenics Pharmaceuticals, Inc.
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Study of Subcutaneous Methylnaltrexone (MNTX) in the Treatment of Opioid-Induced Constipation During Rehabilitation After Orthopedic Procedures PHASE2 The purpose of this study is to examine the safety and activity of MNTX in ...
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Progenics Pharmaceuticals, Inc
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Methylnaltrexone in Patients With Opioid-Induced Bowel Dysfunction PHASE2 This is a double-blind, randomized, parallel group, dose ranging study of s...
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Progenics Pharmaceuticals, Inc.
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