Found 7 matching trials
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients
PHASE1The primary purpose of this protocol is to compare PDE4 levels before and a...
Location
National Institutes of Health Clinical Center, 9000 Rockville Pike
PET Whole Body Biodistribution and Test Retest Bain Imaging Studies Using a Phosphodiesterase 4 Inhibitor (R)-[11C]Rolipram
PHASE1The purpose of this study is to measure a particular protein in the brain c...
Location
National Institutes of Health Clinical Center, 9000 Rockville Pike
Rolipram to Treat Multiple Sclerosis
PHASE2This study will evaluate the safety, tolerability, and effect of the drug R...
Location
National Institute of Neurological Disorders and Stroke (NINDS)
Study of the Inhibition of [11C]R-rolipram Binding to Brain Phosphodiesterase - 4 (PDE-4) by HT-0712
PHASE1This Positron Emission Tomography (PET) imaging study is designed to explor...
Location
Brookhaven National Laboratory
[11C]-(R)-Rolipram to Measure cAMP Signaling Before and After Ketamine
PHASE1Background:
Major depressive disorder (MDD) may have many underlying cause...
Location
National Institutes of Health Clinical Center
PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome
PHASE1Background:
McCune-Albright Syndrome (MAS) is a disorder that affects the ...
Location
National Institutes of Health Clinical Center
Healthy Volunteer Positron Emission Tomography (PET) Brain Occupancy Study of a Phosphodiesterase 4 (PDE4) Inhibitor in Huntington's Disease
PHASE1This study will investigate if a new experimental drug to treat Huntington'...
Location
GSK Investigational Site