Found 18 matching trials
A Study of Recombinant Vaccinia Virus in Combination With Cemiplimab for Renal Cell Carcinoma PHASE1 This is a Phase 1b/2a, open-label, multi-center, dose-escalation and safety...
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Site 2644 University of California, Irvine
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Neoadjuvant Study of Recombinant Vaccinia Virus to Treat Metastatic Colorectal Carcinoma in Patients Undergoing Complete Resection of Liver Tumors PHASE2 This is a neoadjuvant Phase 2a, open-label trial in patients with metastati...
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Ottawa Hospital and Research Institute (OHRI)
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Safety Study of Recombinant Vaccinia Virus to Treat Refractory Solid Tumors PHASE1 This is a Phase I, open-label, dose-escalation trial in patients with advan...
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A Phase 2a Study of Modified Vaccinia Virus to Treat Sorafenib-naïve Advanced Liver Cancer PHASE2 This study is to determine how effectively JX-594 (Pexa-Vec) will prolong l...
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A Phase 2b Study of Modified Vaccinia Virus to Treat Patients Advanced Liver Cancer Who Failed Sorafenib PHASE2 This study is to determine whether JX-594 (Pexa-Vec) plus best supportive c...
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Moores University of California San Diego Cancer Center
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Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma PHASE1 The purpose of this study is to evaluate the safety, tolerability, and effi...
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A Trial to Evaluate the Safety and Efficacy of the Combination of the Oncolytic Immunotherapy Pexa-Vec With the PD-1 Receptor Blocking Antibody Nivolumab in the First-line Treatment of Advanced Hepatocellular Carcinoma (HCC) PHASE1 This is a study to Evaluate the Safety and Efficacy of the Combination of t...
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Phase Ib/II Clinical Study of Pexa-Vec (Vaccinia GM CSF / Thymidine Kinase-Deactivated Virus) Combined With Recombinant Whole Human Anti-PD-L1 Monoclonal Antibody (ZKAB001) in Metastatic Melanoma PHASE1 The study will be divided into two stages: phase Ib and phase II. The safet...
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Beijing Cancer Hospital
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A Study of Pexa-Vec (JX-594) Prior to Sorafenib to Treat Unresectable Primary Hepatocellular Carcinoma PHASE2 The purpose of this pilot safety study is to evaluate the safety and tolera...
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Pusan National University Hospital
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A Study of Metronomic CP and JX-594 in Patients With Advanced Breast Cancer and Advanced Soft-tissue Sarcoma (METROmaJX) PHASE1 Assessment of the efficacy and safety of JX-594 and metronomic cyclophospha...
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Institut Bergonie
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