Found 11 matching trials
First-in-human Phase I Study of a Selective c-Met Inhibitor PLB1001 PHASE1 This phase I, first-in-human dose-escalation study was conducted to determi...
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Guangdong General Hospital
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APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors PHASE2 To assess:
* efficacy of APL-101 as monotherapy for the treatment of NSCLC...
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Cedars-Sinai Medical Center - Samuel Oschin Comprehensive Cancer Institute
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Vebreltinib Plus PLB1004 as the First-line Therapy for Patients With EGFRm+/MET+ Locally Advanced or Metastatic NSCLC. PHASE2 Efficacy and Safety Evaluation of Vebreltinib Plus PLB1004 as the First-lin...
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Guangdong Provincial People's Hospital
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A Study Comparing Two Different Capsules, APL-101 and PLB-1001 Capsules, in Healthy Chinese and Caucasian Participants PHASE1 This is a Phase 1, open-label, multi-center, randomized, 2-period, adaptive...
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New Zealand Clinical Research
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Combination of Vebreltinib and Osimertinib in Patients with EGFR 21 L858R Mutation Advanced NSCLC PHASE2 This is a Prospective, open label, single arm study to evaluate the efficac...
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Active Not Recruiting
Location
Cancer insititue and Hospital of CHINESE ACADEMY OF MEDICAL SCIENCE
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A Study of PLB1001 Enteric Capsules in the Treatment of sGBM/IDH Mutant Glioblastoma Patients With the ZM Fusion Gene (FUGEN). PHASE2 The goal of this clinical trial is to evaluate the safety and efficacy of P...
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Active Not Recruiting
Location
Beijing Tiantan Hospital,Capital Medical University
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Vebreltinib Plus PLB1004 Versus Platinum-based Doublet Chemotherapy in Patients With EGFRm, MET+, Locally Advanced or Metastatic NSCLC Following EGFR-TKI Failure PHASE3 Efficacy and Safety of Vebreltinib in Combination With PLB1004 Versus Plati...
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Multiple Locations
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A Confirmatory Clinical Study in NSCLC Patients With MET Exon 14 Mutation (KUNPENG-2) PHASE3 The goal of this clinical trial is to test if PLB1001 works well and safely...
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Guangdong Provincial People's Hospital
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Study of a c-Met Inhibitor PLB1001 in Patients With PTPRZ1-MET Fusion Gene Positive Recurrent High-grade Gliomas PHASE1 This phase I, open-label, dose-escalation study was conducted to determine ...
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Beijing Shijitan Hospital,CMU
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A Study of PLB1001 in Non-small Cell Lung Cancer With c-Met Dysregulation(KUNPENG) PHASE2 This is a Phase II, open-label, multicenter and multi-cohorts study of PLB1...
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Guangdong General Hospital
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