Found 27 matching trials
Single-Dose Study to Evaluate the PKs of Pretomanid in Participants With Renal Impairment Compared to Participants With Normal Renal Function PHASE1 This is a Phase 1, open-label, single-dose, sequential group study to compa...
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Advanced Pharma - Miami
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Evaluation of the Pharmacokinetic Interaction Between PA-824 and Midazolam PHASE1 The purpose of this study is to determine the safety and tolerability of PA...
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MDS Pharma Services
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Shortening Treatment by Advancing Novel Drugs PHASE3 The purpose of this study is to assess the efficacy, safety and tolerabilit...
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National Center for Tuberculosis and Lung Diseases
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A Study of the Safety, Tolerability, and Absorption, Metabolism, and Excretion of PA-824 in Healthy Adult Male Subjects. PHASE1 This study is a Phase 1, single-center, open-label, single-dose study to ev...
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Covance Clinical Research Unit
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Single-dose Study in Two Panels of Healthy Adult Participants to Assess Immediate-Release and Dispersible Formulations of Pretomanid PHASE1 This is a single-dose, open-label, randomized, four-period, four-treatment,...
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Worldwide Clinical Trials Early Phase Services, LLC
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Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With Clofazimine (C)-TMC207 (J)-PA-824 (Pa)-Pyrazinamide (Z) PHASE2 The trial will evaluate the extended bactericidal activity of 14 consecutiv...
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Centre for Tuberculosis Research Innovation, UCT Lung Institute
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Various Doses and Durations of Linezolid Plus Bedaquiline & Pretomanid in Participants With Drug Resistant Tuberculosis PHASE3 To evaluate the efficacy, safety and tolerability of various doses and dura...
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National Center for Tuberculosis and Lung Diseases
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Phase 2 Trial Assessing TBAJ876 or Bedaquiline, With Pretomanid and Linezolid in Adults With Drug-sensitive Pulmonary Tuberculosis PHASE2 The goal of this clinical trial is to evaluate 3 dose levels of TBAJ876 for...
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Active Not Recruiting
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National Center for Tuberculosis and Lung Diseases
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A Phase 2 to Evaluate the Efficacy, Safety and Tolerability of Combinations of Bedaquiline, Moxifloxacin, PA-824 and Pyrazinamide in Adult Subjects With Drug-Sensitive or Multi Drug-Resistant Pulmonary Tuberculosis. PHASE2 The purpose of this study is to determine the mycobactericidal activity of ...
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The Aurum Institute: Tembisa Hospital
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Food Effect Study on the Bioavailability and PK of PA-824 Tablets in Healthy Adult Subjects PHASE1 This is a Phase 1, single-center, randomized, balanced, single-dose, two-tr...
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MDS Pharma Services
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