Found 14 matching trials
IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) PHASE3 The purpose of this clinical trial is to evaluate efficacy and safety of ti...
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Mayo Clinic Cancer Center
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A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001) PHASE1 This study aims to evaluate the safety, tolerability, pharmacodynamic, and ...
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Active Not Recruiting
Location
Mayo Clinic Hospital ( Site 0140)
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Study to Evaluate Safety and Pharmacokinetics of GS-4059 (Tirabrutinib) in Healthy Volunteers and Participants With Rheumatoid Arthritis (RA) PHASE1 This study will consist of two parts: Part A will evaluate the safety, tole...
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UC Davis Lawrence J. Ellison
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Study to Evaluate the Efficacy, Safety, and Tolerability of Tirabrutinib in Participants With Antihistamine-Resistant Chronic Spontaneous Urticaria PHASE2 The primary objective of this study is to evaluate the efficacy of tirabrut...
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Multiple Locations
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Dose Escalation and Dose Expansion Study of Tirabrutinib in Combination With Other Targeted Anti-cancer Therapies in Adults With B-cell Malignancies PHASE1 The primary objectives of this study are to evaluate the safety, tolerabili...
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Georgetown University Medical Center
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Study to Assess Safety and Efficacy of Filgotinib, Lanraplenib and Tirabrutinib in Adults With Active Sjogren's Syndrome PHASE2 The primary objective of this study is to assess the efficacy of filgotinib...
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AARR Arizona Arthritis & Rheumatology Research
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Study to Assess the Long-term Safety and Efficacy of Tirabrutinib in Adults With Relapsed/Refractory B-cell Malignancies PHASE1 The primary objective of this study is to determine the long-term safety an...
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Study to Evaluate the Safety and Tolerability of Tirabrutinib (ONO/GS-4059) Given as Monotherapy in Participants With Relapsed/Refractory NHL and CLL PHASE1 The primary objective of the study is to evaluate the safety and tolerabili...
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CHRU - Hopital Claude HURIEZ
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Phase I Study Evaluating Tolerability, Safety, Pharmacokinetics, and Efficacy of Combined ONO-4059 and R-MPV Therapy for PCNSL PHASE1 To confirm the tolerability and safety of combined administration of ONO-40...
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Active Not Recruiting
Location
Aichi Cancer Center
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Safety and Efficacy of the Combination of Tirabrutinib and Entospletinib With and Without Obinutuzumab in Adults With Chronic Lymphocytic Leukemia (CLL) PHASE2 The primary objective of this study is to determine the preliminary efficac...
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Studienzentrum Aschaffenburg
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