Found 11 matching trials
Safety and Tolerability of a Single Intra-anal Dose of NRL001 in Healthy Volunteers PHASE1 This study is conducted to explore the safety and tolerability and plasma p...
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University Hospital MHAPT Zaritza Johanna
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A Multi-centre, Phase II, Double-blind, Randomised, Placebo-controlled, Parallel Group, Dose-ranging Study in Patients With Faecal Incontinence; to Evaluate the Efficacy, Safety and Tolerability of Locally Applied NRL001 Over an 8 Week Treatment Period PHASE2 The purpose of this study is to evaluate the safety, tolerability and effic...
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Fakultni Nemocnice BRNO
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Safety and Tolerability of the Twice Daily Intra-anal Application of NRL001 Cream for 14 Days PHASE1 The study is being conducted to evaluate the safety and tolerability after ...
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Multiple Locations
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Safety, Tolerability, Pharmacodynamic and Pharmacokinetics of a Single Rectal Application of 10 mg NRL001 in Elderly Subjects PHASE1 A total of 26 healthy elderly male and female subjects will receive both 10...
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Bio-Kinetic Europe Ltd
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Study to Investigate Safety and Response to 1 or 2 g Rectal Suppositories Containing 5 or 10 mg NRL001. PHASE1 This is a healthy volunteer three-way crossover study. A total of 12 subjec...
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Department of GI Surgery, Nottingham University Hospital
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Study of Escalating Doses of NRL001 Given in Slow-release Rectal Suppositories of Different Weights PHASE1 Studies investigating single doses of different NRL001 formulations showed ...
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Bio-Kinetic Europe Limited
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Effect of 7 Days of Dosing With a 10 mg Rectal Suppository of NRL001in Patients With Faecal Incontinence PHASE1 This is a study to examine the effect of alpha adrenergic stimulation of th...
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Queens Medical Centre
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Effect of Single Doses of 10 mg NRL001 Applied as a Suppository to the Anal Canal or Rectum PHASE1 Study to assess the effects of 10mg NRL001 on mean anal resting pressure (M...
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Division of GI Surgery, University Hospital - Queens Medical Centre
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Evaluation of the Pharmacokinetics of NRL972 Following Pre-Administration of Rifampicin and Cyclosporine PHASE1 A study in healthy volunteers to determine whether different drugs metaboli...
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Dept. Clinical Pharmacology & Therapeutics, MHAPT "Zaritza Johanna" University Hospital
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The Safety and Dose Response to Single Anal Doses of NRL001 PHASE1 Single centre dose-finding and proof-of-concept study in healthy volunteers...
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University Hospital - Queens Medical Centre
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