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Low-Dose or High-Dose Conditioning Followed by Peripheral Blood Stem Cell Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Myelogenous Leukemia PHASE3 RATIONALE: Giving chemotherapy, such as fludarabine phosphate, busulfan, an...
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HealthOne Presbyterian St. Lukes Medical Center
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Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant Cyclophosphamide EARLY_PHASE1 Background:
CGD causes infections and inflammation. The only cure currentl...
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Active Not Recruiting
Location
National Institutes of Health Clinical Center
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Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD) PHASE3 This is a single-dose, open-label study in pediatric participants with seve...
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Active Not Recruiting
Location
Levine Children's Hospital - Hematology
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EDIT-301 for Autologous Hematopoietic Stem Cell Transplant (HSCT) in Participants With Transfusion-Dependent Beta Thalassemia (TDT) PHASE1 The purpose of this study is to evaluate the safety, tolerability, and effi...
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Active Not Recruiting
Location
University of California San Francisco
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Safety and Efficacy of the Lentiviral Vector in Gene Therapy of Beta-thalassemia Patients NA This is a non-randomized, open-label, single-dose study. The aim of this st...
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Institute of Hematology & Blood Diseases Hospital
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Myloablative Cord Blood Transplant in Haematological Malignancies (MAC UCBT) PHASE2 This trial is looking at using umbilical cord blood from unrelated donors a...
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University College London Hospital
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Rasburicase in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer or Other Disease Undergoing Donor Stem Cell Transplant PHASE1 RATIONALE: Rasburicase may be an effective treatment for graft-versus-host ...
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Massachusetts General Hospital
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Comparing Post-Transplant Cyclophosphamide As GVHD Prophylaxis to Standard of Care for Acute Leukemia Patients PHASE3 This randomized clinical trial will evaluate two approaches of GvHD prophyl...
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King Faisal Specialist Hospital & Research Center
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PTCy and Ruxolitinib GVHD Prophylaxis in Myelofibrosis PHASE1 A number of groups have demonstrated very low incidence of acute and chroni...
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First Pavlov State Medical University of St. Petersburg
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GVHD Prophylaxis With Post-transplantation Bendamustine in Refractory Leukemia PHASE1 Several groups have demonstrated very low incidence of acute and chronic gr...
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First Pavlov State Medical University of St. Petersburg
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