Found 13 matching trials
A Study to Evaluate the Absorption, Distribution, Metabolism, Excretion and Absolute Bioavailability of AG-348 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C]AG-348 and Concomitant Single Intravenous Microdose of [13C6]AG-348 PHASE1 This study will assess absorption, distribution, metabolism, excretion and ...
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A Study to Compare the Pharmacokinetics and Safety of Mitapivat 100 mg Tablet Formulation With Mitapivat 2 × 50 mg Tablet Formulation in Healthy Adult Participants PHASE1 The primary purpose of this study is to characterize and compare the pharma...
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PPD Development, LP
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Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell Disease N/A Background:
Sickle cell disease (SCD) is an inherited blood disorder. The ...
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Active Not Recruiting
Location
National Institutes of Health Clinical Center
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A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT) PHASE3 The primary objective of this study was to compare the effect of mitapivat ...
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Location
Phoenix Children's Hospital
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A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT) PHASE3 The primary purpose of this study was to compare the effect of mitapivat ve...
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Active Not Recruiting
Location
San Diego Hospital, UC San Diego Health
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A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP) PHASE2 This clinical trial is a Phase 2/3 study that will determine the recommende...
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Active Not Recruiting
Location
University of California San Diego
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A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathy PHASE2 The primary purpose of this study is to evaluate the effect of mitapivat on...
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Multiple Locations
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A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD) PHASE3 The primary objective of this study is to determine the effect of mitapivat...
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Indiana Hemophilia & Thrombosis Center
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A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Mitapivat (AG-348) in Healthy Adult Participants PHASE1 This is a Phase 1, randomized, single-dose, double-blinded, 4-period, cross...
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PPD Development, LP
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A Dose-Finding Study of AG-348 in Sickle Cell Disease EARLY_PHASE1 Background:
Sickle Cell Disease (SCD) is an inherited blood disorder. Peop...
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National Institutes of Health Clinical Center
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