Found 59 matching trials
Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone (MNTX) in Subjects With Impaired Renal Function
PHASE1This study is evaluating the Pharmacokinetics of MNTX in healthy control su...
Location
Progenics Pharmaceuticals, Inc.
Study Evaluating Subcutaneous MOA-728 for the Treatment of Opioid-Induced Constipation (OIC) in Subjects With Chronic Non-Malignant Pain
PHASE3The primary purpose of the protocol is to evaluate the safety, efficacy, an...
Location
Multiple Locations
Naloxone and Intravenous Methylnaltrexone Effects on Bladder Function
PHASE1This is a double-blind, randomized, study at a single clinical site investi...
Location
Progenics Pharmaceuticals, Inc.
Effect of Methylnaltrexone (MNTX) on Electrocardiogram (ECG) Parameters and Cardiac Repolarization
PHASE1This study will employ a single-center, randomized, double-blind parallel-g...
Location
Progenics Pharmaceuticals
Safety of Subcutaneous Methylnaltrexone for Opioid-Induced Constipation in Patients With Advanced Illness
PHASE4This is an open-label, multicenter extension of study 3200K1-4000-WW that w...
Location
Salix Investigational Site
Effect of Methylnaltrexone (Relistor) on Digestion and Tolerance to Tube Feeding in Patients Treated With Opiates
PHASE3It is hypothesized that using methylnaltrexone in addition to pain killer n...
Location
Hahnemann University Hospital
Study of Pharmacokinetics, Safety and Tolerability of Intravenous Methylnaltrexone Bromide
PHASE1This double-blind, randomized, two-cohort, placebo-controlled, parallel gro...
Location
Progenics Pharmaceuticals, Inc.
Safety and Gastrointestinal Effects of Intravenous Methylnaltrexone
PHASE2This study evaluates the safety of multiple doses of IV MNTX in normal heal...
Location
Progenics Pharmaceuticals, Inc.
Study of the Pharmacokinetics of Intravenous Administered 14C-MNTX
PHASE1This is an open-label, radiotracer study, to be conducted in healthy, norma...
Location
Progenics Pharmaceuticals, Inc.
Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine
PHASE4Ticagrelor is associated with more prompt and potent antiplatelet effects c...
Location
University of Florida