Found 20 matching trials
Study Evaluating Subcutaneous MOA-728 for the Treatment of Opioid-Induced Constipation (OIC) in Subjects With Chronic Non-Malignant Pain
PHASE3The primary purpose of the protocol is to evaluate the safety, efficacy, an...
Location
Multiple Locations
Study Evaluating MOA-728 Administered in Healthy Men
PHASE1Absorption, distribution, metabolism, and excretion (ADME) study with 14C i...
Location
Multiple Locations
Study Evaluating the Effects of MOA-728 on Cardiac Repolarization in Healthy Subjects
PHASE1The purpose of the study is to assess the effects of MOA-728 on cardiac rep...
Location
Multiple Locations
Study Evaluating Long-Term Safety of MOA-728 in Participants With Opioid-Induced Constipation
PHASE3This study is designed to evaluate the long-term safety and tolerability of...
Location
Pfizer Investigational Site
Study Evaluating MOA-728 Oral for the Treatment of OIBD in Subjects With Chronic Non-Malignant Pain
PHASE2The primary purpose of this study is to evaluate the safety and dose-respon...
Location
Multiple Locations
Comparisons Of The Bioavailability And Pharmacodynamics Of Various Formulations Of MOA-728 In Subjects On Methadone
PHASE1Primary: To determine the relative bioavailability of MOA-728, an investiga...
Location
Multiple Locations
Study Evaluating Oral MOA-728 for the Treatment of Opioid-Induced Bowel Dysfunction (OIBD) in Subjects With Chronic Non-Malignant Pain
PHASE2The primary purpose of the protocol is to evaluate the safety, efficacy, an...
Location
Multiple Locations
Dose Ranging Study in Healthy Methadone Maintenance Subjects
PHASE1To assess the effect of a single oral dose of MOA-728, an investigational d...
Location
Multiple Locations
Study Evaluating Subcutaneous Methylnaltrexone For Treatment Of Opioid-Induced Constipation In Patients With Advanced Illness
PHASE4This study will evaluate the safety and efficacy of methylnaltrexone admini...
Location
Salix Investigational Site
Study Evaluating IV Methylnaltrexone for the Treatment of Post Operative Ileus
PHASE3Primary Objective: In subjects who have undergone segmental colectomy, the ...
Location
Multiple Locations