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Osimertinib in Combination With Alisertib or Sapanisertib for the Treatment of Osimertinib-Resistant EGFR Mutant Stage IIIB or IV Non-Small Cell Lung Cancer PHASE1 This phase Ib trial studies the best dose, safety, and effect of alisertib ...
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M D Anderson Cancer Center
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Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Leukemia PHASE2 This phase II trial is studying the side effects of and how well alisertib ...
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Children's Hospital of Alabama
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MLN8237 in Patients With Relapsed or Refractory Aggressive B-Cell Lymphoma Treated With Rituximab +/- Vincristine PHASE1 This is a single-arm, open-label, multicenter, dose escalation, phase 1-2 s...
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Multiple Locations
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Mass Balance, Pharmacokinetics and Metabolism Study of Alisertib PHASE1 The purpose of this study is to assess the mass balance (i.e. cumulative ex...
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Comprehensive Clinical Development
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Study of MLN8237 in Participants With Advanced Hematological Malignancies PHASE1 This is an open-label, multicenter, phase 1 study of MLN8237 in participant...
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Multiple Locations
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A Study of MLN8237, a Novel Aurora A Kinase Inhibitor, in Participants With Advanced Solid Tumors PHASE1 To determine the dose-limiting toxicity (DLT) and maximum tolerated dose (M...
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Sarah Cannon Research Institute (SCRI)
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Alsertib (MLN8237) and Brentuximab Vedotin for Relapsed/Refractory CD30-Positive Lymphomas and Solid Malignancies PHASE1 This is an open label phase I trial designed to evaluate the maximum tolera...
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Houston Methodist Cancer Center
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Combining MLN8237 With Nab-Paclitaxel in Patients With Advanced Solid Malignancies PHASE1 This phase I trial studies the side effects and the best dose of MLN8237 (a...
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Washington University School of Medicine
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Food Effect Study of Alisertib (MLN8237) in Participants With Advanced Solid Tumors or Lymphomas PHASE1 The purpose of this study is to evaluate the effect of food on the single-d...
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Multiple Locations
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Alisertib With or Without Fulvestrant in Treating Patients With Locally Advanced or Metastatic, Endocrine-Resistant Breast Cancer PHASE2 This phase II trial studies how well alisertib with or without fulvestrant ...
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Georgetown University Medical Center
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