Found 12 matching trials
Sphingo-lipotoxicity and Trans-differentiation of Adipose Tissue in Obesity (SFINGOTRANS)
N/AAfter recruiting a population of subjects with different metabolic severity...
Location
Istituto Auxologico Italiano, Site Piancavallo
Tirzepatide: Reversal of Lipotoxicity and Adipose Tissue Dysfunction in Humans With Overweight/Obesity
PHASE2Obesity, affecting 40% of US adults and costing 173b annually, represents a...
Location
Clinical and Translational Research Unit
Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants
PHASE4Our goal of the study is to learn the effects of the diabetes medication na...
Location
Texas Diabetes Institute/UH
Effect of Increased Free Fatty Acids on Leptin Function
NAObese people have elevated levels of the hormone leptin. Despite this, they...
Location
Beth Israel Deaconess Medical Center
Glucolipotoxicity and Type 2 Diabetes
NAElevations of blood glucose and lipid are thought to be deleterious to the ...
Location
Centre of Inflammation and Metabolism, Rigshospitalet
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract
N/ALoss of muscle mass (scientific term: cachexia) affects about 80% of patien...
Location
CHU Clermont-Ferrand
Regression of Fatty Heart by Valsartan Therapy
PHASE4Traditionally, obesity is considered an indirect cause of heart disease. Ob...
Location
University of Texas Southwestern Medical Center
Fat Metabolism in Pregnancy and Neonatal Heart Function in Diabetes
N/ABackground: The health of the next generation is likely programmed in the w...
Location
Washington University
Effects of Acipimox on Insulin Action, Vascular Function, and Muscle Function in Type 1 Diabetes
PHASE3Insulin resistance (IR) is an important contributor to increased cardiovasc...
Location
University of Colorado Denver
Pancreas Lipotoxicity in T2D: Edinburgh Diabetes Remission Study (EDRS)
NAThis study aims to investigate how fat accumulation in the pancreas contrib...
Location
Clinical Research Facility, Royal Infirmary of Edinburgh