Found 8 matching trials
Study of JDQ443 in Comparison With Docetaxel in Participants With Locally Advanced or Metastatic KRAS G12C Mutant Non-small Cell Lung Cancer PHASE3 This is a phase III randomized open label study designed to compare JDQ443 ...
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Active Not Recruiting
Location
Valley Medical Center Research
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JDQ443 for KRAS G12C NSCLC Brain Metastases PHASE2 The goal of this phase II clinical trial is to evaluate the intracranial ef...
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Multiple Locations
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Neoadjuvant Platform Trial in Non-Small Cell Lung Cancer PHASE2 This study is being done to answer the following question: What are the eff...
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Active Not Recruiting
Location
CancerCare Manitoba
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Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation PHASE1 This is Phase Ib/II, multicenter, open-label adaptive platform study of JDQ...
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Active Not Recruiting
Location
Massachusetts General Hospital
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Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation PHASE1 This is a phase Ib/II open label study. The escalation part will characteri...
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Active Not Recruiting
Location
Emory University School of Medicine-Winship Cancer Institute
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A Phase 1 Study to Evaluate the Pharmacokinetics of JDQ443 in Participants With Hepatic Impairment Compared to Matched Healthy Control Participants. PHASE1 The purpose of this study is to evaluate the effect of hepatic impairment o...
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Orlando Clinical Research Center
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Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression < 1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation. PHASE2 This study aims to evaluate the antitumor activity and safety of JDQ443 sin...
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Active Not Recruiting
Location
The Brown University Oncology Group
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Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments PHASE1 The purpose of this study is to allow continued access to opnurasib (JDQ443...
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Novartis Investigative Site
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