Found 32 matching trials
Diagnosis of Leptomeningeal Metastasis and the Monitoring of Intrathecal Chemotherapy Efficacy in NSCLC N/A Non-small cell lung cancer (NSCLC), occupying a disquieting position as the...
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Efficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal Metastases PHASE2 This is a prospective interventional study clinical study to investigate th...
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Hunan Cancer Hospital
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Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases PHASE2 A Single-Arm Clinical Study of Furmonertinib (160mg) Combined with Intrathe...
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CANGZHOU People's Hospital
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Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal Metastasis PHASE1 This phase I/II study is to evaluate the recommended dose, safety, feasibil...
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Active Not Recruiting
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Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine
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Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal Metastasis PHASE1 Leptomeningeal metastasis, characterized by tumor cells infiltrating and pr...
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The Affiliated Huizhou Hospital, Guangzhou Medical University
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Aumolertinib Combined Intrathecal Chemotherapy for Leptomeningeal Metastasis From EGFR-Mutated NSCLC and Prognostic Value of Dynamic Changes in cfDNA Profiles PHASE2 This is a prospective, open-label, single-arm clinical trial. The aim of th...
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chongqing University Three Gorges Hospital
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Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib. PHASE2 Pemetrexed is one of the first-line chemotherapeutic agents for non-squamou...
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The Affiliated Huizhou Hospital, Guangzhou Medical University
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Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis NA Intrathecal chemotherapy is one of the mainstay treatment options for lepto...
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The First Hospital of Jilin University
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Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLC PHASE2 Leptomeningeal metastasis (LM) is a complication of advanced non-small cell...
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Department of Chest Medicine, Taipei Veterans General Hospital
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Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer PHASE1 It has been proved that intrathecal chemotherapy is the main treatment stra...
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The First Hospital of Jilin University
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