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Novel Dose Escalation to Predict Treatment With Hydroxyurea EARLY_PHASE1 Sickle cell disease is a disorder in which red blood cells (RBCs) are abnor...
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Texas Children's Hospital
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Genomic Based Assignment of Therapy in Advanced Urothelial Carcinoma PHASE2 Background:
Advanced urothelial cancer has no cure. But only a few chemoth...
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National Institutes of Health Clinical Center
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Realizing Effectiveness Across Continents With Hydroxyurea (REACH) PHASE1 REACH is a prospective, phase I/II open-label dose escalation trial of hydr...
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Hospital Pediátrico David Bernardino
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Luspatercept With or Without Hydroxyurea for the Treatment of Myelodysplastic/Myeloproliferative Neoplasms With Ring Sideroblasts and Thrombocytosis or Unclassifiable With Ring Sideroblasts PHASE2 This phase II trial studies the effects of luspatercept with or without hyd...
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Mayo Clinic Hospital in Arizona
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Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia PHASE1 Background:
Sickle cell disease (SCD) is an inherited disorder of the bloo...
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Location
National Institutes of Health Clinical Center
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Large-scale Trial Testing the Intensity of CYTOreductive Therapy in Polycythemia Vera (PV) PHASE3 CYTO-PV is a phase III Prospective, Randomized, Open-label, with Blinded En...
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Azienda Ospedaliera Universitaria Ospedali Riuniti di Ancona
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Hydroxyurea to Treat Beta-Thalassemia (Cooley's Anemia) PHASE2 This 12-month study will evaluate the safety and effectiveness of hydroxyur...
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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Pediatric Hydroxyurea in Sickle Cell Anemia (PED HUG) PHASE2 To determine whether hydroxyurea prevents the onset of chronic end organ da...
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Multiple Locations
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Interferon-alfa With or Without Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Newly Diagnosed Chronic Myelogenous Leukemia PHASE3 RATIONALE: Interferon alfa may interfere with the growth of cancer cells. D...
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Hackensack University Medical Center
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Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease PHASE1 Background:
Peripheral blood stem cell transplantation procedures are used...
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Active Not Recruiting
Location
National Institutes of Health Clinical Center
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