🤖 GLOBAL HEALTH OPTIMIZATION AGENT v3.0

🔬 Current Disease Focus:

Task Progress: 0%

👥 Active Problem Solvers

🌍 Experts collaborating globally

⚡ Current Task Assignment

🧬 Genetic Analysis

🔄 Matching experts to specific tasks

📊 Resource Allocation by Research Phase:

📚 Data Analysis

🧪 Experimental Design

🔬 Clinical Trials

💊 Treatment Development

Trial Search

Current Search Criteria:

Intervention: Giredestrant

Found 24 matching trials

A Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared With the Physician's Choice of Endocrine Therapy Plus Everolimus in Participants With Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer (evERA Breast Cancer)

PHASE3

This Phase III, randomized, open-label, multicenter study will evaluate the...

Status

Active Not Recruiting

Location

Alaska Oncology & Hematology, LLC

Start Date

2022-08-03

Trial ID

NCT05306340

Treatments Being Tested

Giredestrant Exemestane Fulvestrant Tamoxifen Everolimus LHRH Agonist Dexamethasone Mouth Rinse

Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-GDC-9545 Following a Single Oral Dose (Part 1) and to Evaluate the Absolute and Relative Bioavailability of Oral Capsule Formulations of GDC-9545 (Part 2) in Healthy Female Subjects of Non-Childbearing Potential

PHASE1

This is an open-label, single-center, two part study in healthy female subj...

Status

Completed

Location

Quotient Sciences

Start Date

2021-01-07

Trial ID

NCT04680273

Treatments Being Tested

[14C]-GDC-9545 GDC-9545 Solution for Infusion GDC-9545/F12 Capsule GDC-9545/F18 Capsule

Preoperative Window Opportunity Study With Giredestrant or Tamoxifen in Premenopausal Women With ER+/HER2[-] & Ki67≥10%

PHASE2

This study is a window of opportunity clinical trial to evaluate the effica...

Status

Completed

Location

Hopital Europeen Georges Pompidou

Start Date

2023-07-20

Trial ID

NCT05659563

Treatments Being Tested

Giredestrant Tamoxifen

A Study of Giredestrant in Participants With Grade 1 Endometrial Cancer

PHASE2

This Phase II, global, single-arm study is designed to evaluate the efficac...

Status

Active Not Recruiting

Location

University of Arkansas for Medical Sciences

Start Date

2023-06-27

Trial ID

NCT05634499

Treatments Being Tested

Giredestrant

A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)

PHASE3

This is a Phase III, global, randomized, open-label, multicenter, study eva...

Status

Active Not Recruiting

Location

Southern Cancer Center

Start Date

2021-08-27

Trial ID

NCT04961996

Treatments Being Tested

Giredestrant Physician's Choice of Endocrine Therapy LHRH Agonist

A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)

PHASE3

This Phase III, randomized, two-arm, open-label, multicenter study will eva...

Status

Active Not Recruiting

Location

Arizona Clinical Research Center, Inc

Start Date

2022-07-18

Trial ID

NCT05296798

Treatments Being Tested

Phesgo Giredestrant Docetaxel Paclitaxel LHRH Agonist Optional Endocrine Therapy of Investigator's Choice

A Study of Giredestrant (GDC-9545) in Postmenopausal Women With Stage I-III Operable, Estrogen Receptor-Positive Breast Cancer

PHASE1

This study will evaluate the pharmacodynamics, pharmacokinetics, safety, an...

Status

Completed

Location

University of Colorado

Start Date

2019-07-26

Trial ID

NCT03916744

Treatments Being Tested

Giredestrant Surgery

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

PHASE1

This is a Phase IB/II multi-cohort study designed to evaluate the efficacy ...

Status

Recruiting

Location

City of Hope Comprehensive Cancer Center

Start Date

2021-10-20

Trial ID

NCT04486352

Treatments Being Tested

Atezolizumab - 28 Day Cycle Bevacizumab Ipatasertib Talazoparib Trastuzumab emtansine Tiragolumab Atezolizumab - 21 Day Cycle Inavolisib Letrozole Giredestrant Abemaciclib

A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)

PHASE3

This Phase III, randomized, double-blind, placebo-controlled, multicenter s...

Status

Active Not Recruiting

Location

Orange Coast Memorial Medical Center

Start Date

2020-10-09

Trial ID

NCT04546009

Treatments Being Tested

Giredestrant Giredestrant-matched Placebo Letrozole Letrozole-matched Placebo Palbociclib LHRH Agonist

A Window-of-Opportunity Trial of Giredestrant +/- Triptorelin vs. Anastrozole + Triptorelin in Premenopausal Patients With ER-positive/HER2-negative Early Breast Cancer

PHASE2

PREcoopERA is a randomized (2:2:1), multicenter, open-label, three-arm (A, ...

Status

Completed

Location

Gustave Roussy Cancer Center

Start Date

2024-01-23

Trial ID

NCT05896566

Treatments Being Tested

Giredestrant Triptorelin Anastrozole

Previous Next