Found 193 matching trials
A Pharmacokinetics Study of the Effects of GSK2118436 on Warfarin, the Effects of Ketoconazole and Gemfibrozil on GSK2118436, and the Effects of Repeat Doses of GSK2118436 in Subjects With BRAF Mutant Solid Tumors PHASE1 GSK2118436 is an orally administered, potent and selective small molecule B...
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GSK Investigational Site
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Dabrafenib, Trametinib, and Spartalizumab for the Treatment of BRAF V600E or V600K Mutation Positive Stage IIIB/C/D Melanoma PHASE2 This phase II trial studies how well dabrafenib, trametinib, and spartalizu...
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M D Anderson Cancer Center
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Safety and Oversight of the Individually Tailored Treatment Approach: A Novel Pilot Study NA This study is looking at outcomes in people with advanced cancers who have ...
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Peter MacCallum Cancer Centre
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Neoadjuvant Therapy With Conservative Surgery vs. Up-front Conservative Surgery for BRAF V600E-Mutated Ameloblastoma PHASE2 Ameloblastoma is the most common benign odontogenic tumor, characterized by...
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Multiple Locations
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Dabrafenib + Trametinib + PDR001 In Colorectal Cancer PHASE2 This research study is studying a combination of drugs as a possible treatm...
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Massachusetts General Hosital Cancer Center
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Dabrafenib and Trametinib Before and After Surgery in Treating Patients With Stage IIIB-C Melanoma With BRAF V600 Mutation PHASE2 This is a single arm phase II trial focused on how dabrafenib and trametini...
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Active Not Recruiting
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M D Anderson Cancer Center
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TraMel-WT: A Trial of Trametinib in Patients With Advanced Pretreated BRAFV600 Wild-type Melanoma PHASE2 This phase 2 trial will investigate the efficacy and safety of trametinib a...
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Universitair Ziekenhuis Brussel
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High Throughput Drug Sensitivity Assay and Genomics- Guided Treatment of Patients With Relapsed or Refractory Acute Leukemia NA This pilot clinical trial studies the feasibility of choosing treatment bas...
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Fred Hutch/University of Washington Cancer Consortium
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A Phase I Study to Investigate the Safety, Tolerability and Pharmacokinetic Profile of of GSK2118436 in Japanese Subjects With BRAF Mutation Positive Solid Tumors PHASE1 BRF116056 is the first clinical experience with GSK2118436, a BRAF inhibito...
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GSK Investigational Site
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A Clinical Trial of Patients With Melanoma PHASE1 This study is being done to find out if the combination of dabrafenib, tram...
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University of Texas Southwestern Medical Center
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