Found 161 matching trials
Pembrolizumab and Trametinib in Treating Patients With Stage IV Non-Small Cell Lung Cancer and KRAS Gene Mutations
PHASE1This phase Ib trial studies the side effects of pembrolizumab and trametini...
Location
University of California Davis Comprehensive Cancer Center
Dabrafenib, Trametinib, and Spartalizumab for the Treatment of BRAF V600E or V600K Mutation Positive Stage IIIB/C/D Melanoma
PHASE2This phase II trial studies how well dabrafenib, trametinib, and spartalizu...
Location
M D Anderson Cancer Center
Dabrafenib + Trametinib + PDR001 In Colorectal Cancer
PHASE2This research study is studying a combination of drugs as a possible treatm...
Location
Massachusetts General Hosital Cancer Center
Dabrafenib and Trametinib Before and After Surgery in Treating Patients With Stage IIIB-C Melanoma With BRAF V600 Mutation
PHASE2This is a single arm phase II trial focused on how dabrafenib and trametini...
Status
Active Not Recruiting
Location
M D Anderson Cancer Center
TraMel-WT: A Trial of Trametinib in Patients With Advanced Pretreated BRAFV600 Wild-type Melanoma
PHASE2This phase 2 trial will investigate the efficacy and safety of trametinib a...
Location
Universitair Ziekenhuis Brussel
Safety, Pharmacokinetics (PK) of AKT and MEK Combination
PHASE1This study is a Phase 1 dose-escalation open-label study to determine the r...
Location
GSK Investigational Site
A Clinical Trial of Patients With Melanoma
PHASE1This study is being done to find out if the combination of dabrafenib, tram...
Location
University of Texas Southwestern Medical Center
Study of GSK1120212 Plus Gemcitabine vs Placebo Plus Gemcitabine in Metastatic Pancreatic Cancer
PHASE2GSK1120212 is a potent and highly selective inhibitor of MEK phosphorylatio...
Location
GSK Investigational Site
Testing the Safety and Effectiveness of Combining Two Drugs, PLX2853 and Trametinib in the Treatment of Advanced Uveal Melanoma
PHASE1This phase I/II trial tests the safety, side effects, and best dose of PLX2...
Location
Multiple Locations
A Study of GSK2256098 and Trametinib in Advanced Pancreatic Cancer
PHASE2This is a phase 2 study (the second phase in testing a new drug or combinat...
Location
Juravinski Cancer Center