Found 12 matching trials
Safety Study of GC1008 in Patients With Focal Segmental Glomerulosclerosis (FSGS) of Single Doses of GC1008 in Patients With Treatment Resistant Idiopathic FSGS PHASE1 This study will investigate whether GC1008, an antibody which neutralizes T...
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Multiple Locations
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Study of GC1008 in Patients With Idiopathic Pulmonary Fibrosis (IPF) PHASE1 This study is designed to investigate whether GC1008, an antibody that neut...
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Multiple Locations
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SABR-ATAC: A Trial of TGF-beta Inhibition and Stereotactic Ablative Radiotherapy for Early Stage Non-small Cell Lung Cancer PHASE1 The SABR-ATAC trial (Stereotactic Ablative Radiotherapy and anti-TGFB Antib...
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Stanford University, School of Medicine
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Fresolimumab In Systemic Sclerosis PHASE1 The purpose of this study is to determine if fresolimumab is safe in treati...
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Boston University School of Medicine; Rheumatology/Arthritis Center
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Anti-TGF Monoclonal Antibody (GC1008) in Relapsed Malignant Pleural Mesothelioma PHASE2 This study is being conducted to evaluate the overall safety and effectiven...
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Abramson Cancer Center of the University of Pennsylvania
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Anti-TGF-beta Therapy in Patients With Myelofibrosis PHASE1 TGF-β is a cytokine that is found to be upregulated in the bone marrow of p...
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Icahn School of Medicine at Mount Sinai
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Safety of Fresolimumab in the Treatment of Osteogenesis Imperfecta PHASE1 Osteogenesis Imperfecta (OI) is a rare disorder that causes bones to break ...
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Oregon Health Science University
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A Study of Fresolimumab in Patients With Steroid-Resistant Primary Focal Segmental Glomerulosclerosis (FSGS) PHASE2 The primary objectives of this trial are as follows:
* to compare the achi...
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Investigational Site Number 4008
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Part 2 of Phase 1 Study of GC1008 to Treat Advanced Melanoma (Part 2 Will Only Accept and Treat Patients With Advanced Malignant Melanoma) PHASE1 Background:
* GC1008 is a genetically engineered antibody designed to bloc...
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Cancer Institute of New Jersey
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Safety and Efficacy Study of GC1008 to Treat Renal Cell Carcinoma or Malignant Melanoma PHASE1 The purpose of this study is to determine the safety, tolerability, pharmac...
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National Cancer Institute (NCI)
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