Found 43 matching trials
Phase Ib Study of Avutometinib, Defactinib, and Everolimus in RAS Pathway Mutant Endometrial Cancer
PHASE1To find the recommended dose of the combination of avutometinib, defactinib...
Location
MD Anderson Cancer Center
Phase I/Ib Study of Paclitaxel in Combination With VS-6063 in Patients With Advanced Ovarian Cancer
PHASE1This is a Phase I/Ib, open-label, multicenter, dose-escalation trial of pac...
Location
Florida Cancer Specialists
ROCKIF Trial: Re-sensitization of Carboplatin-resistant Ovarian Cancer With Kinase Inhibition of FAK
PHASE1The purpose of the study is to investigate the combination VS-6063, carbopl...
Location
University of California San Diego
Stereotactic Body Radiotherapy and Focal Adhesion Kinase Inhibitor in Advanced Pancreas Adenocarcinoma
PHASE2Patients with advanced pancreas adenocarcinoma will be randomized on a 6:1 ...
Status
Active Not Recruiting
Location
Washington University School of Medicine
Defactinib Combined With Pembrolizumab and Gemcitabine in Patients With Advanced Cancer
PHASE1In pancreatic cancer, targeting the tumor microenvironment has become a pro...
Defactinib, Avutometinib and Nivolumab for the Treatment of Anti-PD1 Refractory LKB1-Mutant Advanced Non-Small Cell Lung Cancer
PHASE2This phase II trial tests how well defactinib and avutometinib in combinati...
Location
Emory University Hospital Midtown
Placebo Controlled Study of VS-6063 in Subjects With Malignant Pleural Mesothelioma
PHASE2This study is a Phase 2, randomized, double-blind, placebo-controlled, mult...
Location
University of California San Francisco Medical Center
Stereotactic Body Radiotherapy Plus FAK and RAF/MEK Inhibition in Advanced Pancreatic Adenocarcinoma
PHASE2Advanced pancreatic cancer patients receiving treatment of adaptive stereot...
Location
Washington University School of Medicine
Window of Opportunity Study of VS-6063 (Defactinib) in Surgical Resectable Malignant Pleural Mesothelioma Participants
PHASE2This is an open label neoadjuvant (treatment with VS-6063 prior to mesothel...
Location
Brigham and Women's Hospital
A Study of Avutometinib + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer in Japanese Patients
PHASE2This study will confirm the safety and efficacy of avutometinib in combinat...
Status
Active Not Recruiting
Location
Aichi Cancer Center Hospital