Found 30 matching trials
BAY73-4506 Probe Substrate Study PHASE1 * To evaluate the effect of BAY73-4506 on the pharmacokinetics of probe sub...
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Cross Cancer Institute
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Cocktail Approach for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood Spot PHASE1 Phenotyping is an approach largely used for the evaluation of the activity ...
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University Hospitals
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A Pharmacokinetic Study of RO5185426 in Combination With a Drug Cocktail in Patients With Metastatic Melanoma PHASE1 This open-label single-arm study will evaluate the effect of RO5185426 \[RG...
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UCLA - School of Medicine
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The ECMOCYP (cytochromes P450 Activity) Study N/A Prospective open label observational study including patients requiring a t...
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University Hospital Of Geneva
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Drug Cocktail Interaction Study of St. John's Wort Dry Extract Ze 117 PHASE1 This Study evaluates the Effect of St. John's Wort dry Extract Ze 117 on Se...
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To Determine the Effect of CYP Induction Following Administration of Nirogacestat in Healthy Adult Male Participants PHASE1 This study will evaluate the effects of nirogacestat 100 mg twice daily (BI...
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ICON Martini Groningen CRU
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A Study of Zipalertinib in Patients With Advanced Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions or Other Uncommon Mutation. PHASE2 The purpose of this study is to evaluate the safety, efficacy and pharmacok...
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University of Alabama at Birmingham
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Evaluation of CYP450 Activities in Diabetic Patients vs. Non-diabetic Subjects PHASE4 Type 2 diabetes (T2D) could modulate CYP450 activities involved in drug-met...
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Centre hospitalier de l'Université de Montréal (CHUM)
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A Study to Evaluate the Effect of Oral Doses of JNJ-54175446 on the Inhibition of Cytochrome P450 CYP3A4, CYP2C9, CYP1A2 and CYP2D6 Activity and the Induction of CYP2B6 and CYP2C19 Activity Using a Multiple Probe Substrate Cocktail in Healthy Subjects PHASE1 The main purpose of this study is to determine the potential inhibitory/ind...
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Clinical Pharmacology Unit
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Effects of Repeated Doses of Foliglurax on Drug Metabolizing Enzymes in Healthy Subjects PHASE1 The purpose of this study is to help determine which types of drugs that ma...
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