Found 23 matching trials
Novel PET/CT Imaging Biomarkers of CB-839 in Combination With Panitumumab and Irinotecan in Patients With Metastatic and Refractory RAS Wildtype Colorectal Cancer PHASE1 This phase I/II trial studies the best dose and side effects of glutaminase...
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Vanderbilt-Ingram Cancer Center
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CANTATA: CB-839 With Cabozantinib vs. Cabozantinib With Placebo in Patients With Metastatic Renal Cell Carcinoma PHASE2 Tthe primary objective of this study is to compare blinded Independent Radi...
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University of Alabama at Birmingham
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Study of the Glutaminase Inhibitor CB-839 in Solid Tumors PHASE1 Many tumor cells, in contrast to normal cells, have been shown to require t...
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UCSF Helen Diller Family Comprehensive Cancer Center
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CB-839 in Combination With Niraparib in Platinum Resistant BRCA -Wild-type Ovarian Cancer Patients PHASE1 The purpose of this protocol is to investigate the efficacy of the combinat...
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University of Alabama at Birmingham
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Telaglenastat Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung Cancer PHASE1 This phase Ib trial studies the side effects and best dose of telaglenastat...
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Active Not Recruiting
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University of Alabama at Birmingham Cancer Center
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Impact of a Histamine H2 Receptor Antagonist (H2RA) on the Pharmacokinetics (PK) of Telaglenastat in Healthy Subjects PHASE1 This study is designed to formally evaluate the impact of famotidine, an H2...
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Nucleus Network Brisbane Clinic (formerly Q-Pharm)
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CB-839 + Capecitabine in Solid Tumors and Fluoropyrimidine Resistant PIK3CA Mutant Colorectal Cancer PHASE1 This study has two portions. The main goal of the Phase I portion of this r...
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University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center
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KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated, Nonsquamous NSCLC PHASE2 This is a Phase 2, randomized, multicenter, double-blind study of the gluta...
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University of Alabama at Birmingham
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TEPH: Telaglenastat Efficacy in Pulmonary Hypertension PHASE1 The research study is being conducted to evaluate the effectiveness of a dr...
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UPMC Presybeterian
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CB-839 HCl in Combination With Carfilzomib and Dexamethasone in Treating Patients With Recurrent or Refractory Multiple Myeloma PHASE1 This phase I trial studies the best dose of CB-839 HCl when given together ...
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Active Not Recruiting
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