Found 12 matching trials
First-in-human Phase I Study of a Selective c-Met Inhibitor PLB1001 PHASE1 This phase I, first-in-human dose-escalation study was conducted to determi...
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Guangdong General Hospital
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APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors PHASE2 To assess:
* efficacy of APL-101 as monotherapy for the treatment of NSCLC...
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Cedars-Sinai Medical Center - Samuel Oschin Comprehensive Cancer Institute
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Vebreltinib Plus PLB1004 as the First-line Therapy for Patients With EGFRm+/MET+ Locally Advanced or Metastatic NSCLC. PHASE2 Efficacy and Safety Evaluation of Vebreltinib Plus PLB1004 as the First-lin...
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Guangdong Provincial People's Hospital
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A Study Comparing Two Different Capsules, APL-101 and PLB-1001 Capsules, in Healthy Chinese and Caucasian Participants PHASE1 This is a Phase 1, open-label, multi-center, randomized, 2-period, adaptive...
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New Zealand Clinical Research
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Bozitinib Combined With Chemotherapy as Radical Treatment for Stage IIA-IIIC MET-Altered Non-Small Cell Lung Cancer PHASE2 This study aim to evaluate the efficacy and safety of Bozitinib combined wi...
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Multiple Locations
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Combination of Vebreltinib and Osimertinib in Patients with EGFR 21 L858R Mutation Advanced NSCLC PHASE2 This is a Prospective, open label, single arm study to evaluate the efficac...
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Active Not Recruiting
Location
Cancer insititue and Hospital of CHINESE ACADEMY OF MEDICAL SCIENCE
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APL-501 or Nivolumab in Combination With APL-101 in Locally Advanced or Metastatic HCC and RCC PHASE1 Study Design and Investigational Plan:
This is an open-label Phase 1/2 stu...
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Border Medical Oncology Research Unit
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Vebreltinib Plus PLB1004 Versus Platinum-based Doublet Chemotherapy in Patients With EGFRm, MET+, Locally Advanced or Metastatic NSCLC Following EGFR-TKI Failure PHASE3 Efficacy and Safety of Vebreltinib in Combination With PLB1004 Versus Plati...
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Multiple Locations
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A Real-World Study of Treatment Patterns and Effectiveness in MET Mutation-Positive Advanced Lung Cancer N/A This is a descriptive observational study in which data are collected in an...
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Hunan Province Tumor Hospital
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Study of a c-Met Inhibitor PLB1001 in Patients With PTPRZ1-MET Fusion Gene Positive Recurrent High-grade Gliomas PHASE1 This phase I, open-label, dose-escalation study was conducted to determine ...
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Beijing Shijitan Hospital,CMU
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