Found 90 matching trials
P13Kinase Inhibitor BKM120 in Combination With Panitumumab in Metastatic/Advanced RAS-Wild Type Colorectal Cancer. PHASE1 For the first phase of this study (phase I), the purpose will be to find th...
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BCCA - Vancouver Cancer Centre
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PI3K Inhibitor BKM120 and Docetaxel in Treating Patients With Advanced Solid Tumor That is Locally Advanced, Cannot Be Removed By Surgery, or Metastatic PHASE1 This phase I trial studies the side effects and best dose of PI3K inhibitor...
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Roswell Park Cancer Institute
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NeoPHOEBE: Neoadjuvant Trastuzumab + BKM120 in Combination With Weekly Paclitaxel in HER2-positive Primary Breast Cancer PHASE2 This randomized, parallel cohort, two stage, double-blind, placebo-controll...
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Novartis Investigative Site
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A Dose-finding Study of a Combination of Imatinib and BKM120 in the Treatment of 3rd Line GIST Patients PHASE1 The purpose of this study is to determine a maximum tolerated dose and/or r...
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Dana Farber Cancer Institute SC (2)
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A Trial of Gefitinib in Combination With BKM120 in Patients With Advanced Non-Small Cell Lung Cancer, With Enrichment for Patients Whose Tumours Harbour Molecular Alterations of PI3K Pathway and Known to Overexpress EGFR PHASE1 The safety, tolerability and recommended phase 2 dose (RP2D) of the combina...
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National Cancer Centre Singapore
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Trial of Erlotinib and BKM120 in Patients With Advanced Non Small Cell Lung Cancer Previously Sensitive to Erlotinib PHASE2 Preclinical data in lung cancer cell lines showed that EGFR mutation can po...
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Florida Cancer Specialists South
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A Trial of Irinotecan and BKM120 in Previously Treated Advanced Colorectal Cancer PHASE1 This phase I trial will use the combination of irinotecan and BKM120 in pat...
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University of Kansas Cancer Center
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Dose Finding Study of BKM 120 in Combination With LH-RH Agonists and Bicalutamide in Men With Non Castrate Metastatic Prostate Cancer PHASE1 To determine the maximum-tolerated dose (MTD) of BKM120 when administered o...
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Institut Paoli Calmettes
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Trial of BKM120/Tamoxifen-combination in Patients With HR-pos, HER2-neg Breast Cancer PHASE2 This is a clinical trial with a molecularly stratified parallel cohort, sin...
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Buparlisib in Melanoma Patients Suffering From Brain Metastases (BUMPER) PHASE2 The study will enrol adult female and male patients with BRAF wild-type mel...
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Department of Dermatology, University Hopsital
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