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Intervention: BI 685509

Found 16 matching trials

A Study to Test the Effect of Different Doses of Avenciguat (BI 685509) on Kidney Function in People With Chronic Kidney Disease

PHASE2

This study is open to adults who have kidney disease that is not caused by ...

Status

Completed

Location

Clearview Medical Research, LLC

Start Date

2021-04-27

Trial ID

NCT04736628

Treatments Being Tested

Avenciguat Placebo

A Study in Healthy People to Compare Two Different Tablets of BI 685509 and to Test How Food and Esomeprazole Influence the Amount of BI 685509 in the Blood

PHASE1

The main objective of this trial is to investigate: * the relative bioavai...

Status

Completed

Location

Humanpharmakologisches Zentrum Biberach

Start Date

2024-01-16

Trial ID

NCT06193811

Treatments Being Tested

Avenciguat (BI 685509) (intended commercial formulation (iCF))Avenciguat (BI 685509) (trial formulation 2 (TF2))esomeprazole

A Study to Test How Avenciguat (BI 685509) is Taken up in the Body of People With and Without Liver Problems

PHASE1

This study is open to people with and without severe liver problems. People...

Status

Terminated

Location

Orlando Clinical Research Center

Start Date

2024-05-03

Trial ID

NCT06272058

Treatments Being Tested

Avenciguat (BI 685509)

A Study to Test Whether Avenciguat Helps People With Liver Cirrhosis and High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver) Who Had Bleeding in the Esophagus or Fluid Accumulation in the Belly

PHASE2

This study is open to adults with advanced liver cirrhosis caused by hepati...

Status

Terminated

Location

California Liver Research Institute

Start Date

2024-01-03

Trial ID

NCT06082843

Treatments Being Tested

Placebo Avenciguat

A Study to Test How Different Doses of BI 685509 Are Tolerated in Patients With Liver Problems

PHASE1

The primary objective of this trial is the evaluation of safety and tolerab...

Status

Completed

Location

American Research Corporation at the Texas Liver Institute

Start Date

2019-03-06

Trial ID

NCT03842761

Treatments Being Tested

BI 685509 Placebo

A Study to Test Whether Two Different Doses of Avenciguat Help People With Liver Cirrhosis and High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver)

PHASE2

This study is open to adults with liver cirrhosis and high blood pressure i...

Status

Terminated

Location

California Liver Research Institute

Start Date

2022-04-27

Trial ID

NCT05161481

Treatments Being Tested

Avenciguat (BI 685509)Placebo matching Avenciguat (BI 685509)

A Study in Healthy Men to Find the Best Formulation of BI 685509 and to Test How it is Taken up in the Body

PHASE1

The main objective of this trial is to select a formulation and to optimize...

Status

Completed

Location

Quotient Sciences

Start Date

2021-07-01

Trial ID

NCT04926246

Treatments Being Tested

R1: Reference Product X T1: Test Product M T2: Test Product N T3: Test Product O T4: Test Product O R2: Reference Product Y T5: Test Product P T6: Test Product P T7: Test Product Q R3: Reference Product Z T8: Test Product S T9: Test Product S T10: Test Product U

A Study to Test Whether BI 685509 Alone or in Combination With Empagliflozin Helps People With Liver Cirrhosis Caused by Viral Hepatitis or Non-alcoholic Steatohepatitis (NASH) Who Have High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver)

PHASE2

This study is open to adults with liver cirrhosis caused by hepatitis B, he...

Status

Terminated

Location

California Liver Research Institute

Start Date

2022-06-28

Trial ID

NCT05282121

Treatments Being Tested

Avenciguat Empagliflozin

A Study in People With Systemic Sclerosis to Test Whether Avenciguat (BI 685509) Has an Effect on Lung Function and Other Systemic Sclerosis Symptoms

PHASE2

This study is open to adults aged 18 and older or above legal age who have ...

Status

Completed

Location

University of Alabama at Birmingham

Start Date

2022-12-13

Trial ID

NCT05559580

Treatments Being Tested

Avenciguat (BI 685509)Placebo

This Study Tests a New Medicine Called BI 685509 in Patients That Have Kidney Problems Because of Diabetes. The Study Tests How BI 685509 is Taken up in the Body and How Well it is Tolerated (Multiple Rising Doses)

PHASE1

The main objective of this trial is the safety and tolerability of 3 multip...

Status

Completed

Location

Nephrology Consultants, LLC

Start Date

2017-10-17

Trial ID

NCT03165227

Treatments Being Tested

BI 685509 Placebo

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