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Current Search Criteria:

Intervention: AZD7594

Found 10 matching trials

A Study to Evaluate the Disposition of Drug in Body and Safety After Administration of Single Inhaled Doses of Drugs Abediterol and AZD7594 Administered Alone, in Fixed Dose Combination and in Free Combination Using the Dry Powder Inhaler in Healthy Male Participants

PHASE1

AZD7594 is a non steroidal, potent and selective modulator of the glucocort...

Status

Completed

Location

Research Site

Start Date

2016-11-24

Trial ID

NCT02967159

Treatments Being Tested

Abediterol AZD7594 AZD7594/abediterol AZD7594 and abediterol

Mass Balance Recovery, Pharmacokinetics and Metabolite Profile and Identification of [14C]AZD7594

PHASE1

AZD7594 is in clinical development for the treatment of asthma. This is a ...

Status

Completed

Location

Research Site

Start Date

2019-06-11

Trial ID

NCT04002427

Treatments Being Tested

Intravenous Infusion Inhaled dose

A Study to Evaluate the Amount of Drug That Becomes Available to the Blood Circulation When Inhaled by a Nebulizer and Dry Powder Inhaler in Healthy Subjects.

PHASE1

The purpose of this study is to assess the relative bioavailability of the ...

Status

Completed

Location

Research Site

Start Date

2019-09-19

Trial ID

NCT04072562

Treatments Being Tested

AZD7594

A Study to Assess the Efficacy and Safety of Multiple Dose Levels of AZD7594 Administered Once Daily by Inhalation in Asthmatic Subjects

PHASE2

This study will assess the efficacy and safety of multiple dose levels of A...

Status

Completed

Location

Research Site

Start Date

2019-01-02

Trial ID

NCT03622112

Treatments Being Tested

AZD7594 DPI 55μg/50μg.AZD7594 DPI 99 µg/90 µg AZD7594 DPI 198 µg/180 µg AZD7594 DPI 396 µg/360 µg once daily.AZD7594 DPI 792 µg/720 µg Placebo for AZD7594 once daily.FF 100 µg once daily (open-label)

A Study to Assess the Effect of Particle Size of AZD7594 on Pharmacokinetics (PK) After a Single Inhaled Dose When Administered Using the Dry Powder Inhaler in Healthy Volunteers

PHASE1

This study is an open label, randomized, three-way crossover study to asses...

Status

Completed

Location

Research Site

Start Date

2016-11-25

Trial ID

NCT02928354

Treatments Being Tested

Treatment A - AZD7594 Treatment B - AZD7594 Treatment C - AZD7594

A Study to Assess the Pharmacokinetics (PK), Pharmacodynamics (PD) and Safety of 2-Week Treatment With Inhaled AZD7594 in Adolescents (12 to 17 Years) With Asthma

PHASE1

This is an open-label, multi-centre, Phase I study to assess the PK, PD and...

Status

Completed

Location

Research Site

Start Date

2019-07-24

Trial ID

NCT03976869

Treatments Being Tested

AZD7594

A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD7594 Inhaled Formulation in Healthy Japanese Men

PHASE1

This is a randomized, single-blind, placebo-controlled, sequential-group st...

Status

Completed

Location

Research Site

Start Date

2016-01-12

Trial ID

NCT02645253

Treatments Being Tested

AZD7594 inhalation powder (200 μg)AZD7594 inhalation powder (400 μg)AZD7594 pressurized inhalation suspension (200 μg)AZD7594 placebo inhalation powder AZD7594 placebo pressurized inhalation suspension

A Study to Assess the Bioavailability and to Compare the Pharmacokinetics of AZD7594 Inhaled Via Monodose Inhaler and Multiple-dose Dry Powder Inhalers (DPI) or Pressurized Metered-dose Inhaler (pMDI) in Healthy Male Subjects

PHASE1

This is an open-label,partially randomized, four-period study in healthy ma...

Status

Completed

Location

Research Site

Start Date

2016-01-12

Trial ID

NCT02648438

Treatments Being Tested

AZD7594 Solution for infusion (150 μg intravenous formulation)AZD7594 Oral suspension (1200 μg oral formulation)AZD7594 Inhalation powder (400 μg) by DPI Device 1 (monodose inhaler)AZD7594 Inhalation powder (400 μg) by DPI device 2 (multiple-dose inhaler)AZD7594 Pressurized inhalation suspension (400 μg) by pMDI

To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ascending Doses of Inhaled AZD7594

PHASE1

The purpose of this study is to evaluate the safety profile and look at lev...

Status

Completed

Location

Research Site

Start Date

2012-09

Trial ID

NCT01636024

Treatments Being Tested

AZD7594 Placebo to match

A Multiple Dosing (14 Days) Study to Assess Efficacy and Safety of Three Dose Levels of AZD7594, Given Once Daily by Inhalation, in Patients With Mild to Moderate Asthma

PHASE2

This study will be a randomised, double-blind, multiple dose (14 days), pla...

Status

Completed

Location

Research Site

Start Date

2015-06-25

Trial ID

NCT02479412

Treatments Being Tested

800 μg AZD7594 once daily 250 µg AZD7594 once daily 58 µg AZD7594 once daily Placebo once daily Salbutamol

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