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Trial Search

Current Search Criteria:

Intervention: AZD4144

Found 11 matching trials

A Phase I Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD4144

PHASE1

This Phase I, open-label, parallel group study will investigate the single ...

Status

Not Yet Recruiting

Location

Research Site

Start Date

2026-08-24

Trial ID

NCT07783308

Treatments Being Tested

AZD4144

A Phase 1b Study to Assess the Safety, Tolerability, and Pharmacodynamics of AZD4144 in Participants With Established Atherosclerotic Cardiovascular and Chronic Kidney Disease.

PHASE1

The purpose of this study is to evaluate the safety, tolerability and the p...

Status

Completed

Location

Research Site

Start Date

2024-12-09

Trial ID

NCT06675175

Treatments Being Tested

AZD4144 Placebo

A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4144 as Well as the Impact of AZD4144 on the Pharmacokinetics of Rosuvastatin and Furosemide in Healthy Participants

PHASE1

This study consists of 3 parts: Part A, Part B and Part C. This study will ...

Status

Completed

Location

Research Site

Start Date

2024-07-15

Trial ID

NCT06491550

Treatments Being Tested

AZD4144- Part A Placebo- Part A AZD4144- Part B Placebo- Part B Rosuvastatin and Furosemide- Part C Rosuvastatin, Furosemide, and AZD4144 Part C

A Study to Investigate the Relative Bioavailability of 2 Different Formulations of AZD4144, the Effect of Food and Omeprazole on the Pharmacokinetics of AZD4144 in Healthy Participants

PHASE1

The main aim of this study to compare the pharmacokinetics (PK) of two form...

Status

Completed

Location

Research Site

Start Date

2025-04-23

Trial ID

NCT06948006

Treatments Being Tested

AZD4144 Omeprazole

A Study to Investigate How AZD4144 Affects the Pharmacokinetics of Rosuvastatin in Healthy Participants

PHASE1

The purpose of this study is to evaluate the pharmacokinetics (PK) of rosuv...

Status

Completed

Location

Research Site

Start Date

2025-04-17

Trial ID

NCT06925854

Treatments Being Tested

AZD4144 Rosuvastatin

A Study of Absorption, Distribution, Metabolism and Excretion (ADME) of [14C]AZD4144

PHASE1

This study in healthy volunteers aims to explore blood levels and side effe...

Status

Completed

Location

Research Site

Start Date

2026-02-11

Trial ID

NCT07518459

Treatments Being Tested

[14C]AZD4144 Solution for Infusion [14C]AZD4144 Oral Solution

A Study to Investigate the Safety, Tolerability and Pharmacodynamics of AZD4144 in Participants With Obesity

PHASE1

The aim of this study is to evaluate the safety and tolerability, and pharm...

Status

Completed

Location

Research Site

Start Date

2025-04-22

Trial ID

NCT06942923

Treatments Being Tested

AZD4144 Placebo

A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

PHASE2

This study will enroll adults aged 18 to 80 years diagnosed with sepsis due...

Status

Recruiting

Location

Research Site

Start Date

2026-02-10

Trial ID

NCT07215702

Treatments Being Tested

AZD4144 Placebo

Investigating the Effect of Itraconazole on the Pharmacokinetics of AZD4144 in Healthy Participants

PHASE1

The purpose of the study is to assess the pharmacokinetics (PK) of AZD4144 ...

Status

Recruiting

Location

Research Site

Start Date

2026-07-30

Trial ID

NCT07685600

Treatments Being Tested

AZD4144 AZD4144 Itraconazole

A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4144 Following Single and Multiple Ascending Doses Via Oral Administration to Healthy Participants

PHASE1

This study will evaluate the safety, tolerability, pharmacokinetics (PK), a...

Status

Completed

Location

Research Site

Start Date

2023-11-07

Trial ID

NCT06122714

Treatments Being Tested

AZD4144 Part A AZD4144 Part B Placebo Part A Placebo Part B

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