Found 10 matching trials
APG-115 Alone or in Combination With APG-2575 in Recurrent or Refractory Neuroblastoma or Solid Tumors
PHASE1An open, non-randomized Phase Ib-II trial of dose-escalation and cohorts ex...
Location
Sun Yat-sen University Cancer Center
A Study of APG-115 Alone or Combined With Azacitidine in Patients With AML, CMML, or MDS
PHASE1This is a two Part study in patients with relapsed/refractory acute myeloid...
Location
Banner MD Anderson Cancer Center
A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors
PHASE1This study aims to assess the safety, tolerability, pharmacokinetics, and p...
Status
Active Not Recruiting
Location
University of Arizona Cancer Center
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma
PHASE2Background:
Mesothelioma is a rare cancer typically caused by exposure to ...
Location
National Institutes of Health Clinical Center
APG-115 in Combination With PD-1 Inhibitor in Patients With Advanced Liposarcoma or Advanced Solid Tumors
PHASE1Part 1 is a phase Ib standard "3 + 3" design, will be employed to determine...
Location
Sun Yat-sen University Cancer Center
APG-115 in Salivary Gland Cancer Trial
PHASE1This is a phase I/II trial to evaluate the efficacy of APG-115 +/- Carbopla...
Status
Active Not Recruiting
Location
Moffitt Cancer Center
A Phase Ib Study of APG-115 Single Agent or in Combination With Azacitidine or Cytarabine in Patients With AML and MDS.
PHASE1Acute myeloid leukemia is a malignant disorder characterized by the rapid, ...
Location
The First Hospital of Peking University
A Study Evaluating APG-115 as a Single Agent or in Combination With APG-2575 in Subjects With R/R T-PLL and NHL
PHASE2The goal of this study is to evaluate the pharmacokinetics (PK), safety, an...
Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNST
PHASE1This is a phase 0/1/2, multi-site study to evaluate the MEK inhibitor Selum...
Location
Children's National Hospital
APG-115 in Patients With Advanced Solid Tumors or Lymphomas
PHASE1APG-115 is a novel, orally active small-molecule mouse double minute 2 homo...