Found 40 matching trials
A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100) PHASE1 Evaluate the safety and tolerability of sotorasib in adult subjects with KR...
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City of Hope National Medical Center
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AMG510 (sotorasib) Plus Lenvatinib As Second-line Treatment in Patients with KRASG12C Mutant, Metastatic NSCLC PHASE2 AMBER is a multicentre, single-arm phase II trial. The protocol treatment c...
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Medical University of Innsbruck / UK für Innere Medizin V
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A Study to Evaluate the Impact of Acid-reducing Agents on the Pharmacokinetics (PK) of AMG 510 in Healthy Participants PHASE1 The primary objective of this study is to evaluate the PK of AMG 510 alone ...
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Covance Clinical Research Unit, Inc
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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial PHASE2 This ComboMATCH patient screening trial is the gateway to a coordinated set...
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University of Alabama at Birmingham Cancer Center
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Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation PHASE3 The aim of this study is to compare progression free survival (PFS) in trea...
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Ironwood Cancer and Research Centers Scottsdale
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Real World Evaluation of Sotorasib Among Chinese Non-Small Cell Lung Cancer Patients N/A The primary objective of this study is to characterize the safety profile o...
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Boao Evergrande International Hospital
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Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer PHASE1 This phase I trial tests the safety, side effects, and best dose of carfilz...
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City of Hope Medical Center
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Study to Evaluate the Drug-drug Interactions Between Metformin and AMG 510 in Healthy Participants PHASE1 The primary objectives of this study are to evaluate the effect of AMG 510 ...
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Covance Clinical Research Unit
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Effect of Coadministration of Sotorasib on the Pharmacokinetics of Rosuvastatin in Healthy Participants PHASE1 A study to determine the effect of sotorasib on the pharmacokinetics (PK) o...
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Covance Clinical Research Unit - Daytona Beach
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A Study in Healthy Volunteers to Compare the Pharmacokinetics of Sotorasib Administered as 1 or 2 Tablets PHASE1 The primary objective of the study is to compare the pharmacokinetics (PK) ...
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Labcorp Clinical Research Unit - Daytona Beach
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