Found 13 matching trials
Study of Orally Administered AG-881 in Patients With Advanced Solid Tumors, Including Gliomas, With an IDH1 and/or IDH2 Mutation PHASE1 This study evaluates the safety, pharmacokinetics, pharmacodynamics and cli...
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UCLA Oncology Center
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Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive IDH-1 Mutant Glioma PHASE1 Vorasidenib in combination with pembrolizumab in participants with recurren...
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Active Not Recruiting
Location
University of Alabama at Birmingham
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Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO) PHASE3 Study AG881-C-004 is a phase 3, multicenter, randomized, double-blind, plac...
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Active Not Recruiting
Location
University of Alabama at Birmingham
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A Safety and Pharmacokinetic Study of AG-881 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C] AG-881 and Concomitant Intravenous Microdose of [13C315N3] AG-881 PHASE1 The purpose of this Phase I, open-label study is to evaluate the absorption...
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Covance Clinical Research Unit Inc.
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A Study to Evaluate AG-881 in Healthy Japanese and Non-Asian Participants PHASE1 The purpose of this study is to compare the pharmacokinetics (PK) and safet...
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Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations PHASE1 This is an open-label, multi-center Phase 1 study of LY3410738, an oral, co...
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Active Not Recruiting
Location
City of Hope National Medical Center
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A Study to Evaluate the Effect of AG-881 on the Pharmacokinetics of a Single Dose of Lamotrigine in Healthy Adults PHASE1 The main purpose of this study is to examine the effect of multiple doses o...
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A Study to Compare the Relative Bioavailability of Two AG-881 Formulations and Evaluate the Effect of Food and Omeprazole on the Pharmacokinetics of AG-881 PHASE1 The purpose of this study is to compare the single-dose pharmacokinetics (P...
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Study of Orally Administered AG-881 in Patients With Advanced Hematologic Malignancies With an IDH1 and/or IDH2 Mutation PHASE1 The purpose of this Phase I, multicenter study is to evaluate the safety, p...
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Multiple Locations
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Phase 3 Study of Vorasidenib (S095032/AG-881) in Asian Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 orIDH2 Mutation PHASE3 The objective of this study is to determine the efficacy, safety, and pharm...
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Active Not Recruiting
Location
The Second People's Hospital of Shenzhen
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