A Study to Evaluate the Absorption, Distribution, Metabolism, Excretion and Absolute Bioavailability of AG-348 in Healthy Male Participants Following Administration of a Single Oral Dose of [14C]AG-348 and Concomitant Single Intravenous Microdose of [13C6]AG-348
PHASE1
This study will assess absorption, distribution, metabolism, excretion and ...
Pyruvate Kinase Deficiency Global Longitudinal Registry Substudy of Protocol AG348-C-008
N/A
This is a substudy of Study AG348-C-008, an observational, longitudinal, mu...
Status
Completed
Location
Massachusetts General Hospital
Start Date
2021-07-02
Trial ID
NCT04995315
A Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in Pediatric Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)
PHASE3
The primary objective of this study is to compare the effect of mitapivat v...
Status
Recruiting
Location
Weill Cornell Medical College/ New York Presbyterian
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat
PHASE1
Background:
Sickle cell disease (SCD) is a disorder that causes episodes o...
A Study to Compare the Pharmacokinetics and Safety of Mitapivat 100 mg Tablet Formulation With Mitapivat 2 × 50 mg Tablet Formulation in Healthy Adult Participants
PHASE1
The primary purpose of this study is to characterize and compare the pharma...